川崎病冠状动脉损害高危因素的研究

目的 从Kobayashi评分体系及血管紧张素Ⅰ转化酶(angiotensin converting enzyme,ACE)基因多态性两方面探讨川崎病(Kawasaki Disease,KD)患儿的冠状动脉损害的高危因素.方法 住院川崎病患儿137例,其中无冠脉损害120例,有冠脉损害为17例.根据Kobayashi等提出的最新的川崎病并发冠状动脉损害的高危评分指标对患儿的临床资料进行统计学分析;选取其中的37例川崎病患儿(其中8例有冠状动脉损害)和37名健康儿童,用PCR方法 检测其外周血ACE基因多态性,并进行统计学分析.结果 Kobayashi评分体系各单项临床指标在冠脉损害组和无冠脉损害组比较差异无统计学意义(P>0.05);冠脉损害组Kobayashi总评分为1.75±1.65,无冠脉损害组为1.66±1.55,两组比较差异无统计学意义(P>0.05).ACE各基因型(Ⅱ、DD、ⅠD)在冠脉损害组和无冠脉损害组、川崎病组和对照组之间比较差异无统计学意义(P>0.05);Ⅰ等位基因频率在冠脉损害组中明显高于无冠脉损害组(75.0%比44.8%),差异有统计学意义(P<0.05).Kobayashi各单项指标在ACE各基因型之间比较差异无统计学意义(P>0.05).结论 川崎病冠脉损害组和无冠脉损害组Kobayashi各单项指标及总评分差异相似;ACE的Ⅰ/D基因多态性可能与川崎病并发冠脉损害有关.

Study on risky factors of the coronary artery lesion in Kawasaki disease

Objective To investigate the risky factors of the coronary artery lesion (CAL) in Kawasaki disease (KD) by Kobayashi score and genetic polymorphism of angiotensin converting enzyme (ACE) gene. Methods Data of 137 hospitalized KD patients, including 120 patients with CAL and 17 without CAL, were analyzed by Kobayashi score. Genotype of ACE gene were determined in 37 KD patients, including 8 with CAL, and 37 healthy children using polymerase chain reaction (PCR) . Results No significant differences were found...