Adrenal insufficiency and diabetes mellitus secondary to the use of topical corticosteroids for cosmetic purpose |
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Authors: | Sobngwi E Lubin V Ury P Timsit F-J Gautier J-F Vexiau P |
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Affiliation: | Department of Endocrinology and Diabetes, St-Louis University Hospital, 1 Avenue Claude Vellefaux, 75010 Paris, France. e.sobngwi@wanadoo.fr |
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Abstract: | We report a case of symptomatic topical corticosteroid-induced adrenal insufficiency and diabetes in a 46-yr old HIV 1 positive woman of African descent. Topical Betamethasone dipropionate 0.05%-containing creams were used for the purpose of bleaching over a 2 month period prior to the acute episode. She recovered from her acute onset diabetes with ketosis and adrenal insufficiency a few months after withdrawal of corticosteroids. Despite possible discussion about pathophysiology of diabetes because acute-onset remitting diabetes is not rare in patients of African descent, and diabetes may occur in patients taking anti-retroviral treatments, no other cause of a hypothalamo-pituitary-adrenal axis disorder was found. This case suggests that chronic use of high dose topical corticosteroid containing creams should be ruled out in patients presenting with Hypothalamo-Pituitary-Adrenal hypofunction. |
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