| c-myc和p53蛋白在宫颈癌组织中的表达及临床意义 |
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| 引用本文： | 郭昕.c-myc和p53蛋白在宫颈癌组织中的表达及临床意义[J].中国局解手术学杂志,2005,14(3):147-148. |
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| 作者姓名： | 郭昕 |
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| 作者单位： | 佳木斯大学附属第一医院妇产科 黑龙江佳木斯154002 |
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| 摘 要： | 目的探讨c myc和p53蛋白在宫颈癌中表达的临床意义。方法采用免疫组化法检测51例正常宫颈、宫颈上皮内瘤样病变(CIN)和宫颈鳞癌中的c myc和p53蛋白的表达,并用TUNEL法检测细胞凋亡数。结果正常宫颈c myc和p53未见表达,宫颈鳞癌c myc和p53表达高于CIN(P<0.05)。宫颈鳞癌和CIN的TUNEL标记率均低于正常宫颈,宫颈鳞癌与CIN及正常组比较相差非常显著(P<0.01)。结论细胞凋亡可能与宫颈癌的形成过程有关,c myc和p53蛋白过度表达在宫颈癌的发生发展中起很重要的作用。
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| 关 键 词： | 宫颈癌 c-myc p53 基因表达 |
| 文章编号： | 1672-5042(2005)03-0147-02 |
| 修稿时间： | 2005年1月25日 |
Expression and clinical significance of c-myc and p53 protein in cervical carcinoma tissues |
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| GUO Xin.Expression and clinical significance of c-myc and p53 protein in cervical carcinoma tissues[J].Journal of Regional Anatomy and Operative Surgery,2005,14(3):147-148. |
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| Authors: | GUO Xin |
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| Abstract: | Objective To investigate the expression of c-myc and p53 protein in cervical carcinoma tissues and their clinical significance. Methods Immunohistochemistry was used to examine the expression of c-myc and p53 protein in 6 normal cervical tissues and 19 cervical squamous carcinoma tissues and 26 cervical intraepithelial neoplasia (CIN)tissues. The apoptosis amount was detected by TUNEL. Results The expression of c-myc and p53 protein showed an increasing tendency from 6 normal cervical tissues to 26 CIN tissues, then to 19 cervical squamous carcinoma tissues. The TUNEL-positive cells in those carcinoma tissues were significantly lower than that of the normal tissues (P<0.01). Conclusion Apoptosis takes part in genesis of cervical carcinoma and the overexpression of c-myc and p53 protein plays an important role in the development and malignant changes of cervical carcinoma. |
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| Keywords: | cervical carcinoma c-myc p53 gene expression |
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