萎缩性胃炎伴隆起糜烂与环氧合酶-2、c-met癌基因蛋白的关系

目的观察萎缩性胃炎伴隆起糜烂组织环氧合酶(COX)-2、c-met癌基因蛋白的表达情况,探讨其与胃癌发生的关系。方法对萎缩性胃炎伴隆起糜烂、非萎缩性胃炎及胃癌各50例患者的胃镜活检组织进行免疫组织化学检查,比较COX-2、c-met癌基因蛋白的表达情况。结果3组间c-met表达阳性率的差异有统计学意义(P=0.012),萎缩性胃炎伴隆起糜烂组显著高于非萎缩性胃炎组(P=0.050),但与胃癌组的差异无统计学意义(P=0.260)。3组间COX-2表达阳性率的差异有统计学意义(P=0.018),萎缩性胃炎伴隆起糜烂组显著高于非萎缩性胃炎组(P=0.006),但与胃癌组的差异无统计学意义(P=0.817)。结论COX-2、c-met癌基因蛋白在萎缩性胃炎伴隆起糜烂组织均存在高表达,提示萎缩性胃炎伴隆起糜烂胃黏膜病变细胞处在高度增殖状态,并具有恶化倾向。

Expression of cyclooxygenase-2 and c-met proteins in atrophic gastritis with convex erosion

Objective To study the expressions of cyclooxygenase(COX)-2 and c-met proteins in the tissue of atrophic gastritis with convex erosion.Methods The expressions of COX-2 and c-met proteins were detected with immunohistochemistry in 50 specimens of atrophic gastritis with convex erosion,50 chronic superficial gastri- tis and 50 gastric carcinoma tissues.Results c-met protein expression was significantly higher in the atrophic gas- tritis tissue than in superficial gastritis tissue(P=0.050),but similar between the atrophic gastritis and carcinoma tissues(P=0.260).COX-2 expression was also significantly higher in the atrophic gastritis than in the superficial gastritis tissues(P=0.006),and comparable between the atrophic gastritis and gastric carcinoma tissues(P= 0.817).Conclusion High expressions of COX-2 and c-met proteins are present in atrophic gastritis with convex erosion, suggesting highly active proliferation of the cells in the involved gastric mucosa,which may give rise to carcinogenesis.