Carbapenem-resistant and OXA-23-producing Acinetobacter baumannii isolates in the United Arab Emirates |
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Authors: | P Mugnier L Poirel M Pitout P Nordmann |
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Institution: | Service de Bactériologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Facultéde Médecine et UniversitéParis Sud, Bicêtre, France;and Sheikh Khalifa Medical City, Microbiology Department, Abu Dhabi, United Arab Emirates |
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Abstract: | Five carbapenem-resistant Acinetobacter baumannii isolates, collected from the United Arab Emirates in 2006, were investigated to identify the mechanism(s) responsible for carbapenem resistance. Genotyping was performed by pulsed-field gel electrophoresis, and the location of the bla OXA-23 gene was determined by using the endonuclease I Ceu I technique and mating-out assays. The four isolates in which the bla OXA-23 gene was located on the chromosome within a Tn 2006 composite transposon were clonally related. The single non-clonally related isolate harboured the bla OXA-23 gene on a 70-kb transferable plasmid. This study reports on the dissemination of OXA-23-producing A. baumannii isolates in the Middle East. |
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Keywords: | Acinetobacter baumannii carbapenem resistance OXA-23 transposon United Arab Emirates |
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