KAI1蛋白在人胃癌中的表达及临床意义

目的:通过研究KAI1蛋白在胃癌组织中的表达水平,预测其与胃癌生物学行为的关系,探讨其对胃癌的发生、浸润和转移的作用;通过对胃癌组织KAI1蛋白的表达,评估胃癌浸润和转移的潜能,判断预后,及对胃癌的治疗提供新的思路。方法:免疫组化方法对30例胃癌患者组织及正常胃黏膜组织的KAI1蛋白表达分别进行检测。手术标本病理均证实为胃癌,周围正常组织距离癌组织6cm以上。患者术前均未接受任何抗肿瘤治疗。结果:30例胃癌组织中KAI1蛋白表达阳性6例,占20.0%;正常胃黏膜组织中KAI1蛋白阳性表达28例,占93.3%,两者有显著差异。KAI1蛋白表达与胃癌的病理分化程度、临床分期及淋巴结转移呈负相关(P<0.05)。结论:KAI1蛋白在胃正常黏膜组织中的阳性表达明显高于在胃癌组织中的阳性表达,KAI1蛋白表达与胃癌的病理类型、临床分期、淋巴结转移呈负相关,提示KAI1基因具有抑制胃癌浸润和转移作用。

Expression and Clinicopathologic Significance of KAI1 Protein in Gastric Carcinoma

Objective:To explore the level of expression of KAI1 protein in gastric carcinoma(GC) and its relation with biological behavior correlated to GC and its role in the development,invasion and metastasis of GC.The result of study may be useful indicator of the prognosis,invasion and metastasis of GC.It seems to give us a new way to cure GC.Methods:30 cases of GC and 30 cases normal gastric mucosa were detected with immunohistochemistry respectively.Each specimen from patients with GC contains primary carcinoma tissue and normal tissue around carcinoma tissue with the distance more than 6cm.All patients didn't receive any antineoplaston.Results:The positive expression rate of KAI1 protein in gastric tissue was 20%(6 in 30 cases) and that of in normal gastric tissue was 93.3%(28 in 30cases).The result was significantly different;The abnormal expression of KAI1 was closely correlated to the grade of tumor differentiation、tumor stage and lymph node metastasis(P <0.05).Conclusions: The positive expression of KAI1 Protein in normal gastric tissue was significantly higher than that of in gastric carcinoma tissue;The abnormal expression of KAI1 was closely correlated to the grade of tumor differentiation、tumor stage and lymph node metastasis,which means that KAI1 gene can suppress invasion and metastasis of gastric carcinoma in some degree.