| 全反式维甲酸治疗APL所致维甲酸综合征患者的临床疗效分析 |
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| 引用本文： | 黄贵年.全反式维甲酸治疗APL所致维甲酸综合征患者的临床疗效分析[J].亚太传统医药,2011,7(3):79-80. |
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| 作者姓名： | 黄贵年 |
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| 作者单位： | 中山巿人民医院,广东,中山,528403 |
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| 摘 要： | 目的:探讨全反式维甲酸(ATRA)治疗急性早幼粒细胞(APL)所致维甲酸综合征(RAS)患者有效处理方法。方法:本院2001年10月—2010年2月收治APL初治患者95例,治疗中出现维甲酸综合征20例,分别采用加用激素、联合化疗、维甲酸原量、维甲酸减量的治疗方法,分析其发生原因,并总结治疗效果。结果:本组未出现维甲酸综合征的患者治疗后完全缓解(CR)率为85.3%,部分缓解率(PR)为10.7%,恶化及死亡率为4.0%,而出现维甲酸综合征的患者的完全缓解率为65.0%,部分缓解率为15.0%,恶化死亡率为25.0%。结论:RAS是影响ATRA治疗APL完全缓解率的主要因素,临床出现RAS时要及时采取措施阻断RAS的发生发展,提高患者完全缓解率。
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| 关 键 词： | 全反式维甲酸 急性早幼细胞白血病 维甲酸综合征 |
Clinical Analysis of Due to All-trans Retinoic Acid Therapy in Patients with Retinoic Acid Syndrome |
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| Huang Guinian.Clinical Analysis of Due to All-trans Retinoic Acid Therapy in Patients with Retinoic Acid Syndrome[J].Asia-Pacific Traditional Medicine,2011,7(3):79-80. |
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| Authors: | Huang Guinian |
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| Institution: | Huang Guinian(Zhongshan Municipal People's Hospital,Guangdong 528403,China) |
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| Abstract: | Objective:To explore the clinical outcome of reti-noic acid syndrome(RAS)in acute promyelocytic(APL) patients treated with all-trans retinoic acid(ATRA).Methods:95 cases of ALP untreated patients in our hospital from October 2001 to February 2010 admitted in February of APL were treated by hormone,combination chemotherapy,ATRA and ATRA reduction.Then,we analyzed the causes,and summarized therapeutic efficacy.Results:CR rate of patients with no RAS was 85.3%,partial response rate of PR was 10.7%,progression ... |
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| Keywords: | All-trans Retinoic Acid Acute Promyelocytic Leukemia Retinoic Acid Syndrome |
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