对1例骨折截肢术后老年患者使用利奈唑胺的药物监测

1例70a女性患者,因右股骨远端骨折合并双下肢动脉硬化闭塞症、高血压、类风湿性关节炎入院。入院后由于右足感染不能控制,行右大腿上段截肢术。术后合并血流感染和肺内感染,根据细菌培养结果,给予利奈唑胺600mg,q12h,ivgtt。3d后患者出现转氨酶ALT、AST分别升高至163IU·L-1、541IU·L-1,白细胞和血小板减少,遂将利奈唑胺剂量调整为400mg,q12h,ivgtt,后转氨酶恢复正常。停药后,白细胞和血小板恢复正常。

Medication monitoring of linezolid on a senile patient with femoral fracture amputation

A 70-year-old female patient suffered from right distal femoral fracture accompanied with both lower extremities arteriosclerosis obliterans, hypertension and rheumatoid arthritis was hospitalized. Amputation of superior segment of right thigh was operated, because the infection of right foot could not be controlled. After operation, the hematological and pulmonary infections occurred. According to the result of germiculture, linezolid 600 mg twice daily was administered by intravenous drip. Three days later, the levels of ALT and AST increased to 163 IU·L-1 and 541 IU·L-1 respectively, and she also developed leukopenia and thrombocytopenia. When the dosage of linezolid was adjusted to 400 mg twice daily, the levels of hepatic transaminases returned to normal. After linezolid was discontinued, leucocyte and thrombocyte counts returned to normal.