结直肠癌组织5-脂氧合酶的表达与患者临床病理因素的关系

目的 探讨结直肠癌组织中5-脂氧合酶（5-LOX）的表达与患者临床病理因素的关系.方法 采用免疫组化SP法检测52例结直肠癌患者肿瘤组织中5-LOX的表达,分析5-LOX与结直肠癌患者临床病理因素的关系.结果 52例结直肠癌标本中,5-LOX表达阳性者38例（73.1％）.5-LOX阳性表达率淋巴结转移组[87.8％（36/41）]高于无转移组 [18.2％（2/11）,P＜0.05],浸润较深组[T3～T4,81.1％（30/37）]高于浸润较浅组[T1～T2,53.3％（8 /15）,P＜0.05]；Ⅲ、Ⅳ期组[79.5％（31/39）]高于Ⅰ、Ⅱ期组[53.8％（7/13）,P＜0.05]；低分化和未分化组 [100％（24/24）]高于高、中分化组[50.0％（14/28）,P＜0.05]；而肿瘤大小、脉管侵犯、腹膜转移与5-LOX阳性表达率无关. 结论 5-LOX在结直肠癌组织中的阳性表达与肿瘤淋巴转移、浸润深度、分化程度和TNM分期有关.

Association of 5-lipoxygenase expression and clinicopathological factors in colorectal carcinoma

Objective To examine the association of 5-lipoxygenase （5-LOX） expression with clinicopathological factors in colorectal cancer.Methods Immunohistochemical stain was used to detect the 5-LOX expression in 52 resected specimens of colorectal cancer.The association between 5-LOX expression and clinicopathological factors was examined.Results The positive rate of 5-LOX expression in 52 specimens of colorectal carcinoma was 73.1% （38/52）.In 41 colorectal cancer specimens with lymph node metastasis,the positive rate of 5-LOX expression was higher than that in the specimens without metastasis（87.8% vs.18.2%,P〈0.05）.The positive rate of 5-LOX expression in the specimens with deep infiltration （T3 and T4） was higher than that in the specimens with superficial infiltration（T1 and T2）（81.1% vs.53.3%,P〈0.05）.The positive rate of 5-LOX expression in TNM stage Ⅲ and Ⅳ cancer was higher than that in stage Ⅰ and Ⅱ （79.5% vs.53.8%,P〈0.05）.The positive rate of 5-LOX expression in cancers of poor differentiation and non-differentiation adenocarcinoma was higher than that of well and moderately differentiated cancer （100% vs.50.0%,P〈0.05）.There were no significant differences of 5-LOX expression with tumor size,vascular invasion and peritoneal dissemination.Conclusion 5-LOX expression in colorectal carcinoma is closely associated with lymph node metastasis,infiltration depth,differentiation degree and TNM stage.