| 脑型脂肪酸结合蛋白在急性脑梗死检测方面的临床意义 |
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| 引用本文： | 张黎军,邱晨红,王锋,孙沁怡,周华,沈蓉,赵中. 脑型脂肪酸结合蛋白在急性脑梗死检测方面的临床意义[J]. 卒中与神经疾病, 2011, 18(4): 215-218. DOI: 10.3969/j.issn.1007-0478.2011.04.007 |
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| 作者姓名： | 张黎军 邱晨红 王锋 孙沁怡 周华 沈蓉 赵中 |
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| 作者单位： | 南京医科大学附属苏州医院东区神经内科(苏州市立医院东区),苏州,215001 |
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| 基金项目： | 苏州市科教兴卫基金SWKQ0922 |
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| 摘 要： | 目的探讨脑型脂肪酸结合蛋白（B-FABP）在急性脑梗死（ACI）发病过程中的动态变化及临床意义。方法采用ELISA检测100例ACI患者发病l d内、第7d和第l4d内的血清B-FABP,分析其与梗死部位、大小及神经功能缺损的关系。结果 100例脑梗死患者发病l d内、第7d和第l4d血清B-FABP含量水平均明显高于对照组（P〈0.01）,其中在急性期（发病1d内）B-FABP敏感性达68%;腔隙性梗死组B-FABP水平明显高于其它三组（P〈0.01）,全前循环梗死组的B-FABP水平高于后循环梗死组与部分前循环梗死组（P〈0.05）,后循环梗死组高于部分前循环梗死组（P〈0.05）;B-FABP水平在小病灶梗死组高于大病灶梗死组、中病灶组（P〈0.01）,而大病灶梗死组高于中病灶组（P〈0.05）;B-FABP水平在轻型组高于重型组、中型组（P〈0.01）;重型组高于中型组（P〈0.05）。结论 ACI患者血清中B-FABP水平变化与梗死部位、大小和病情严重程度有关,其高敏感性可作为早期诊断脑梗死的潜在、快速的生物学指标。
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| 关 键 词： | 脑型脂肪酸结合蛋白 急性脑梗死 ELISA 生物学指标 |
Clinical significance of the detection of serum B-FABP in patients with acute cerebral infarction |
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| Zhang Lijun,Qiu Chenhong,Wang Feng,et al.. Clinical significance of the detection of serum B-FABP in patients with acute cerebral infarction[J]. Stroke and Nervous Diseases, 2011, 18(4): 215-218. DOI: 10.3969/j.issn.1007-0478.2011.04.007 |
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| Authors: | Zhang Lijun Qiu Chenhong Wang Feng et al. |
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| Affiliation: | Zhang Lijun,Qiu Chenhong,Wang Feng,et al.Department of Neurology,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou 215001 |
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| Abstract: | Objective To explore clinical significance of brain-type fatty acid binding protein(B-FABP) in early diagnosis of patients with acute cerebral infarction.Methods Serum concentrations of B-FABP were detected by using enzyme-linked immunosorbent assay(ELISA)in 100 patients admitted within 24 hours,7 days and 14 days after cerebral infarction,while the relationships between serum concentrations of B-FABP and size,location and neurologic impairment of cerebral infarction were analyzed.50 healthy subjects were s... |
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| Keywords: | ELISA |
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