| 妇科肿瘤与APC基因启动子甲基化研究进展 |
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| 引用本文： | 颜彦,陈勇. 妇科肿瘤与APC基因启动子甲基化研究进展[J]. 肿瘤研究与临床, 2011, 23(6): 428-430. DOI: 10.3760/cma.j.issn.1006-9801.2011.06.025 |
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| 作者姓名： | 颜彦 陈勇 |
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| 作者单位： | 1. 430061,武汉,湖北中医药大学临床医学院04级中医七年制班;湖北医药学院附属太和医院妇科
2. 湖北医药学院附属太和医院妇科 |
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| 基金项目： | 湖北省教育厅自然科学重点项目，湖北省杰出青年人才项目，湖北省自然科学基金，湖北省教育厅中青年人才项目 |
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| 摘 要： | 腺瘤性结肠息肉病（APC）基因是Wnt信号转导通路重要的抑癌基因，其启动子区域的异常甲基化可影响APC基因mRNA的转录和APC蛋白的表达，导致Wnt信号转导通路异常。近年来在妇科肿瘤的多项研究中发现了APC基因启动子区域异常甲基化，其与肿瘤的发生、发展有关。现就APC基因启动子甲基化与妇科肿瘤的研究进展进行综述。
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| 关 键 词： | 腺瘤性结肠息肉病基因 甲基化 妇科肿瘤 |
Research development of APC gene promoter methylation in gynecological cancer |
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| YAN Yan,CHEN Yong. Research development of APC gene promoter methylation in gynecological cancer[J]. Cancer Research and Clinic, 2011, 23(6): 428-430. DOI: 10.3760/cma.j.issn.1006-9801.2011.06.025 |
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| Authors: | YAN Yan CHEN Yong |
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| Affiliation: | YAN Yah, CHEN Yong, CHEN Shuang-yun. Department of Clinical Medicine, Hubei University of Chinese Medicine, Wuhan 430061, China |
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| Abstract: | Adenomatous polyposis coli gene is an important anti-oncogene of the Wnt signaling pathway. The promoter hypermethylation of APC gene can effect the expression of APC mRNA and APC proteinum, which can make Wnt signaling pathway anomalous. Recently. the promoter hypermethylation of APC Gene in gynecological tumors is found in many studies, and it is related to the aggravation level of tumor.This paper reviews the influencing factors and progress of promoter methylation of APC gene in Gynecological cancer. |
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| Keywords: | Adenomatous polyposis coli gene Methylation Gynecological cancer |
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