| 高压氧对神经病理性痛大鼠的疼痛行为学影响 |
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| 引用本文： | 韩光,孟凌新,李璐,姚鹏,崔健君. 高压氧对神经病理性痛大鼠的疼痛行为学影响[J]. 中国疼痛医学杂志, 2011, 17(6). DOI: 10.3969/j.issn.1006-9852.2011.06.011 |
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| 作者姓名： | 韩光 孟凌新 李璐 姚鹏 崔健君 |
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| 作者单位： | 1. 中国医科大学附属盛京医院,麻醉科,沈阳,110004
2. 中国医科大学附属盛京医院,疼痛科,沈阳,110004 |
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| 基金项目： | 沈科技合(10140)号计划项目(F10-205-1-41) |
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| 摘 要： | 目的:观察高压氧(HBO)对神经病理性痛大鼠的疼痛行为学影响及有效性.方法:40只雄性SD大鼠随机分成5组:即空白对照组(C组)、假手术组(M组)、坐骨神经慢性缩窄手术组(CCI组)、高压氧预处理组(Pre-H组)与高压氧干预组(Post-H组),对其疼痛行为学指标进行比较.结果:Pre-H组和Post-H组的机械性缩足反射阈值(MWT)较CCI组明显升高;热缩足反射潜伏期(TWL)较CCI组明显延长.HBO在热痛模型中显示的作用大子机械痛模型;Pre-H的作用大于Post-H.结论:高压氧对CCI大鼠神经病理性疼痛有一定的抑制作用.
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| 关 键 词： | 高压氧 神经病理性疼痛 |
THE EFFECTS OF HYPERBARIC OXYGEN ON NEUROPATHIC PAIN IN RATS |
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| HAN Guang,MENG Ling-Xin,LI Lu,YAO Peng,CUI Jian-Jun. THE EFFECTS OF HYPERBARIC OXYGEN ON NEUROPATHIC PAIN IN RATS[J]. Chinese Journal of Pain Medicine, 2011, 17(6). DOI: 10.3969/j.issn.1006-9852.2011.06.011 |
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| Authors: | HAN Guang MENG Ling-Xin LI Lu YAO Peng CUI Jian-Jun |
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| Affiliation: | HAN Guang,MENG Ling-Xin,LI Lu,YAO Peng,CUI Jian-Jun(Department of Anesthesia,Shengjing Hospital of China Medical University,Shenyang 110004) |
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| Abstract: | Objective:To evaluate the efficacy of hyperbaric oxygen(HBO) treatment on neuropathic pain in chronic constrictive injury(CCI) rats.Methods: Forty male SD rats were randomly divided into five groups: Control(C) group,Mock(M) group,CCI group,Pre-H group,Post-H group.Pain was assessed by mechanical withdrawal thresholds(MWT) and thermal paw withdrawal latencies(PWL).Results: The mechanical withdrawal thresholds of Pre-H group and Post-H group were significant higer than those of CCI group,and thermal withdraw... |
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| Keywords: | Hyperbaric oxygen Neuropathic pain |
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