应用兔VX2移植瘤模型进行正电子发射断层显像-计算机体层成像的初步研究

目的建立兔VX2移植瘤模型，选择合理正电子发射断层显像-计算机体层成像（PET-CT）显像时间；对兔VX2移植瘤模型应用于PET．CT影像研究的可行性进行评价。方法应用日本大耳白兔20只，行软组织悬液穿刺法接种，建立兔VX2移植瘤模型，于肿瘤生长〉2cm后，进行PET。CT扫描。结果软组织悬液穿刺法接种2周后，肿瘤平均直径〉2em，肿瘤体积平均值为（114．57±9．87）cm^3，肿瘤组织最大标准摄取值（SUVmax）为5．85±0．92，对侧正常肌肉组织SUVmax为0．22±0．09，二者差异有统计学意义（t=27．22，P〈0．01）。肿瘤组织SUVmax与其体积无相关性（r=0．02，P=0．93）。结论临床型PET—CT对兔VX2移植瘤显像清晰，是良好显像方法，VX2移植瘤适合进行PET—CT研究。合理的显像时间是接种后14d。

PET-CT imaging preliminary study based on VX2 rabbit xenografts model

Objective To establish the model of VX2 soft tissue xenograft in rabbit, and choose the best time for PET-CT imaging. To analyze the result of the imaging with semi-quantitative, and evaluate the feasibility of the study with VX2 soft-tissue tumor model in rabbit for PET-CT imaging. Methods 20 Japanese white rabbits were successfully implanted with VX2 tumors in thighs by the injection of tissue mass suspension.Then they were scanned with PET-CT after the diameter of the tumor is ＞2 cm. Results The diameter of the tumor＞2 cm at 14 d post implant. The average volume of tumor was (114.57±9.87) cm3.The average SUVmax of tumor's and normal tissue's in the other thigh was 5.85±0.92 and 0.22±0.09 (t=27.03, P＜0.01). SUVmax was not associated with tumor volume (r=0.02, P=0.93).Conclusion The imaging of VX2 soft tissue xenograft is clear by clinic PET-CT, and it is suitable for the study of PET-CT.PET-CT imaging performed at 14 d post implantation had the highest imaging quality.