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| POKemon、p14ARF基因链在大肠癌细胞系的表达及其临床意义 | |
| 引用本文： | 王俊兰,郝素华,李亚玲. POKemon、p14ARF基因链在大肠癌细胞系的表达及其临床意义[J]. 肿瘤研究与临床, 2010, 22(Z1). DOI: 10.3760/cma.j.issn.1006-9801.2010.增.011 |
| 作者姓名： | 王俊兰 郝素华 李亚玲 |
| 作者单位： | 1. 山西省肿瘤医院医保科,太原,030013 2. 山西省肿瘤医院防保科,太原,030013 3. 山西省肿瘤医院病理科,太原,030013 |
| 摘 要： | 目的 研究POKemon、p14ARF基因在结直肠癌细胞系中的表达情况.方法 采用反转录.聚合酶链反应(RT-PCR)、细胞免疫化学技术检测POKemon、p14ARF在5种人类结直肠癌细胞中的表达.结果 POKemon在SW480、SW480/M5、LOVO、SW620中阳性表达,在HCT116阴性表达;p14ARF在HCT116阳性表达,其余细胞均阴性表达.结论 结直肠癌细胞系中存在POKemon的表达,且与p14ARF作用呈负相关. |
| 关 键 词： | 肠肿瘤 POKemon基因 p14ARF基因 |
Expression and clinical significance of POKemon and p14ARF in colorectal carcinoma cells lines |
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| WANG Jun-lan,HAO Su-hua,LI Ya-ling. Expression and clinical significance of POKemon and p14ARF in colorectal carcinoma cells lines[J]. Cancer Research and Clinic, 2010, 22(Z1). DOI: 10.3760/cma.j.issn.1006-9801.2010.增.011 | |
| Authors: | WANG Jun-lan HAO Su-hua LI Ya-ling |
| Abstract: | Objective To study the expression of POKemon and pl4ARF genes in colorectal cancer cell lines. Methods The expressions of POKemon and pl4ARF were detected in 5 human colorectal cancer cell lines by RT-PCR and immucytochemistry method. Results The expressions of POKemon were positive in cell lines of SW480, SW480/M5, SW620 and LOVO, and were negative in HCT116. The expression of pl4ARF was positive in HCT116 and negative in other cell lines. Conclusion POkemon is expressed positively in colorectal cancer cell lines and its function is negatively correlated with pl4ARF. |
| Keywords: | Intestinal neoplasms POKemon pl4ARF Colorectal cancer |
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