Survivin在子宫颈癌中的表达及其临床意义

目的 探讨Survivin的表达及其与子宫颈癌发生、发展的关系.方法 采用免疫组织化学(SP)方法 检测Survivin在40例子宫颈癌组织、38例子宫颈非典型增生组织、10例正常子宫颈组织中的表达情况,并对其与临床病理的关系进行分析.结果 免疫组织化学法测得Survivin在子宫颈癌组织中的阳性表达率60%(24/60)]高于子宫颈非典型增生42.1%(16/38)]和正常子官颈组织(0),差异具有统计学意义(P<0.05);Survivin基因的阳性表达率与子宫颈癌的组织学分级和临床分期有关.结论 Survivin可能与子宫颈癌的发生、发展有关.

Abstract：

Objective To investigate the expression of Survivin gene and the relationship between Survivin and genesis and development of cervical cancer. Methods The expression of Survivin gene in tissues of 40 patients with cervical cancer, 38 patients with cervical hyperplasia and 10 cases of normal cervical were detected by immunohistochemical SP method, and the relationships between Survivin and the clinical pathological factors were analyzed. Results The expression positive rate of Survivin in cervical cancer tissues (60 %) was significantly higher than that in cervical hyperplasia and normal cervical tissues (42.1 % and 0, respectively), and their differences were statistically significant (P < 0.05). The positive expression rate of Survivin was related with histological grade and the clinical stages of cervical cancer.Conclusion Survivin is related to the genesis and development of cervical cancer.

Expression and clinical significance of Survivin in cervical cancer

Objective To investigate the expression of Survivin gene and the relationship between Survivin and genesis and development of cervical cancer. Methods The expression of Survivin gene in tissues of 40 patients with cervical cancer, 38 patients with cervical hyperplasia and 10 cases of normal cervical were detected by immunohistochemical SP method, and the relationships between Survivin and the clinical pathological factors were analyzed. Results The expression positive rate of Survivin in cervical cancer tissues (60 %) was significantly higher than that in cervical hyperplasia and normal cervical tissues (42.1 % and 0, respectively), and their differences were statistically significant (P < 0.05). The positive expression rate of Survivin was related with histological grade and the clinical stages of cervical cancer.Conclusion Survivin is related to the genesis and development of cervical cancer.