| 环氧合酶-2、血管内皮生长因子在透明细胞性肾细胞癌中的表达及其与肿瘤发生、发展的关系 |
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| 引用本文： | 常保东,曹林升,张力,葛永超,邱晓辉,郑涛,郭全喜. 环氧合酶-2、血管内皮生长因子在透明细胞性肾细胞癌中的表达及其与肿瘤发生、发展的关系[J]. 肿瘤研究与临床, 2011, 23(6): 368-371. DOI: 10.3760/cma.j.issn.1006-9801.2011.06.003 |
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| 作者姓名： | 常保东 曹林升 张力 葛永超 邱晓辉 郑涛 郭全喜 |
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| 作者单位： | 1. 郑州市第三人民医院泌尿外科,450000
2. 福建医科大学第一附属医院泌尿外科 |
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| 基金项目： | 郑州市医学科技攻关项目 |
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| 摘 要： | 目的探讨环氧合酶-2（COX-2）、血管内皮生长因子（VEGF）表达与透明细胞性肾细胞癌（CCRCC）患者预后的关系。方法应用免疫组织化学EnVision法检测80例CCRCC患者肿瘤组织和20例输尿管癌或肾盂癌患者正常肾组织中COX一2、VEGF的表达情况，结合临床病理参数分析二者与CCRCC患者预后的关系。结果COX-2在CCRCC组织中的阳性表达率为65．00％（52／80），显著高于正常肾组织中的10．00％（2／20）（x^2=7．760，P=0．021）；VEGF在CCRCC中的阳性表达率为61．25％（49／80），高于正常肾组织中的20.00％（4／20）（X^2=8．870，P=0．012）。COX-2的表达和CCRCCTNM分期（X^2=8．200，P=0．005）、组织学分级（X^2=13．860，P=0．000）以及淋巴结转移（X^2=6．050，P=0．001）有相关性，而与年龄（X^2=0．560，P=0．663）和肿瘤大小（x^2=0．700，P=0．528）无相关性；CCRCC组织中COX-2和VEGF的表达呈正相关（r=0．485，P〈0．01）。COX-2、VEGF的表达和CCRCC患者预后相关（分别为X^2=18．280，P=0．038；X^2=6．420，P=0．042）。结论COX-2和VEGF在CCRCC组织中的表达与肿瘤的发生、发展及预后密切相关，可以作为CCRCC患者的预后指标。
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| 关 键 词： | 环氧合酶2 血管内皮生长因子 预后 免疫组织化学 肾肿瘤 |
Expressions of cyclooxgenase 2 and vascular endothelial growth factor in human clear cell renal cell carcinoma and their relationships with occurrence and development of tumor |
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| CHANG Bao-dong,CAO Lin-sheng,ZHANG Li,GE Yong-chao,QIU Xiao-Hui,ZHENG Tao,GUO Quan-xu. Expressions of cyclooxgenase 2 and vascular endothelial growth factor in human clear cell renal cell carcinoma and their relationships with occurrence and development of tumor[J]. Cancer Research and Clinic, 2011, 23(6): 368-371. DOI: 10.3760/cma.j.issn.1006-9801.2011.06.003 |
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| Authors: | CHANG Bao-dong CAO Lin-sheng ZHANG Li GE Yong-chao QIU Xiao-Hui ZHENG Tao GUO Quan-xu |
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| Affiliation: | CHANG Bao-dong, CAO Lin-sheng, ZHANG Li, GE Yong-chao, QIU Xiao-Hui, ZHENG Tao, GUO Ouan-xi. Department of Urolog), the Third People Hospital of Zhengzhou City, Zhengzhou 450000, China |
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| Abstract: | Objective To investigate the expression of cyclooxgenase 2 (COX-2) and vascular endothelial growth factor (VEGF) in clear cell renal cell carcinoma (CCRCC) and their correlation with Prognosis. Methods EnVision immunohistochemistry was used to determine the expression of COX-2 and VEGF in 80 CCRCC tissues and 20 normal kidney tissues .The relationship between the above marks and prognosis were analyzed. Results The positive rates of COX-2[65.00 % (52/80) vs 10.00 % (2/20), x2= 7.760, P= 0.021]and VEGF[61.25 % (49/20) vs 20.00 (4/80),x2 = 8.870, P= 0.012]were much higher in CCRCC than those in normal kidney. The expression of COX-2 was correlated with TNM stage (x2 = 8.200,P =0.005), histological grade (x2 = 13.860, P = 0.000) and lymph node metastasis (x2 = 6.050, P = 0.001) in CCRCC, but not with age (x2 = 0.560, P = 0.663) and diameter of tumor (x2 = 0.700, P = 0.528). Both COX-2 expression and VEGF expression were associated significantly with prognosis in CCRCC (x2 = 18.280,P = 0.038;x2 = 6.420, P= 0.042, respectively). There was a positive correlation between COX-2 and VEGF in CCRCC (r =0.485, P < 0.01). Conclusion COX-2 is related to prognosis in CCRCC and can be used as prognostic indicators in patients. |
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| Keywords: | Cyclooxygenase 2 Vascular endothelial growth factor Prognosis Immunohistochemistry Clear cell renal cell carcinoma |
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