| 钙通道阻滞药对人肝脏缺血再灌注损伤的保护作用 |
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| 引用本文： | 李铁,王曙光.钙通道阻滞药对人肝脏缺血再灌注损伤的保护作用[J].中华普通外科杂志,2002,17(4):214-216. |
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| 作者姓名： | 李铁 王曙光 |
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| 作者单位： | 1. 118000,丹东市,解放军第二三○医院普通外科
2. 重庆市,第三军医大学西南肝胆外科医院 |
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| 摘 要： | 目的观察钙通道阻滞药维拉帕米对人肝脏缺血再灌注损伤的保护作用。方法对切除肝叶或肝段的患者 ,肝门阻断前经胃网膜右静脉缓慢推注维拉帕米 5mg/ 2ml。结果术后实验组血清酶 (GPT、GOT)和血清吲哚氰绿滞留试验 (ICGR15)的升高幅度、以及动脉血酮体比值 (AKBR)的降低幅度均明显低于对照组 ,且复常时间早 ;肝门阻断后 ,对照组肝细胞内游离钙定量为 (2 99± 32 )nmol/L ,实验组为 (2 14± 41)nmol/L ,组间差异有非常显著意义 (P <0 0 1) ;光学显微镜检查 ,实验组肝细胞病理损伤程度比对照组轻。结论肝门阻断前经门静脉应用钙通道阻滞剂对人肝脏缺血再灌注损伤具有明显的保护作用
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| 关 键 词： | 再灌注损伤 钙通道阻滞药 维拉帕米 肝脏缺血 |
| 修稿时间： | 2001年3月28日 |
Protective effect of calcium channel blocking agents against human hepatic ischemia-reperfusion injury |
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| Abstract: | ObjectiveTo investigate the protective effect of calcium channel blocker, verapamil against human hepatic ischemia-reperfusion injury.MethodsThe patients undergoing lobe/segment hepatectomy were injected with 5?mg/2ml verapamil through vena gastroepiploica dextra before blocking hepatic portal.ResultsThe levels of free calcium ions in the hepatic cell and serum enzyme from the test group increased significantly than those of the control group. The degree of hepatic pathological injury was lower and the hepatic function restored earlier in test group.ConclusionCalcium channel blockers administered by hepatic portal vein before blocking hepatic portal have an important protective effect against human hepatic ischemia-reperfusion injury. |
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| Keywords: | Reperfusion injury Calcium channel blockers Verapamil |
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