血必净治疗脓毒症患者临床疗效观察

目的：观察中药血必净注射液对脓毒症治疗效果。方法：选脓毒症患者40例随机，分为2组。对照组和血必净组，每组20例。治疗组和对照组分别如何治疗，监测患者体温并分别于治疗前、治疗3d、治疗7d采静脉血栓测血常规、c-反应蛋白（CRP）、TNF-a，IL-8。结果：2组患者治疗均有效，血必净组体温、白细胞计数较对照组水平下降，血TNF—a、IL-8及CRP浓度随病情好转，浓度随之下降，血必净组下降明显，28d病死率及住ICU时间较对照组下降。结论：中药血必净能够降低炎症介质水平，改善脓毒症顸后，缩短住ICU时间，从而降低总住院费用。

Clinical Effectiveness and Impact of Xuebijing Injection on Inflammatory Cytokines of Septic Patients

Objective：To investigate the clinical effectiveness of Xuebijing injection on septic patients. Methods：Forty patients were randomized to control group （n = 20） and xuebijing group （n = 20）. Both groups were treated according to 2008 sepsis guideline. Xue- bijing group added xuebijing 100mL ＋ 0. 9% NS lOOmL, bid, 7days for one period. Body temperature was monitored and 3ml blood was collected before treatment, 3days and 7days after treatment and stored in -80℃. TNF-a, IL-8 and CRP were determined by the method of ELISA and immunoturbidimetry. Conclusion： Xuebijing injection can degrade inflammatory cytokines, improve sepsis progno- sis, and reduce the length of ICU stay, so the expense of hospitalization can be decreased.