| 化瘀中药加核糖核酸在治疗小鼠溃疡性结肠炎中对TNF－α的影响 |
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| 引用本文： | 宋明福,刘,敏.化瘀中药加核糖核酸在治疗小鼠溃疡性结肠炎中对TNF－α的影响[J].世界中医药,2013,8(1):74-75. |
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| 作者姓名： | 宋明福 刘 敏 |
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| 作者单位： | 三峡大学中医临床医学院,湖北省宜昌市中医医院,宜昌,443000 |
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| 基金项目： | 湖北省重点科技发展项目立项课题 |
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| 摘 要： | 目的：观察化瘀中药加核糖核酸在治疗小鼠溃疡性结肠炎中对TNF—α的影响。方法：选择小鼠42只，雌雄兼用，如何分组分为对照组、RNA、氟哌酸治疗组。治疗8d后测TNF—α的量的变化。结果：经RNA治疗后，查TNF-α水平降至正常（P〈0．01）。对照组及氟哌酸组如何。结论：化瘀中药加RNA治疗溃疡性结肠炎疗效明显，能使这一内科顽症在短时间内恢复，其作用机制之一是降低血清TNF-α水平。
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| 关 键 词： | 溃疡性结肠炎 肿瘤坏死因子 化瘀药 核糖核酸 |
| 收稿时间： | 2012/6/25 0:00:00 |
Effect of Stasis Removing Herbs plus RNA-based Drugs on TNF- alpha in Mice with Ulcerative Colitis |
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| Song Mingfu,Liu Min.Effect of Stasis Removing Herbs plus RNA-based Drugs on TNF- alpha in Mice with Ulcerative Colitis[J].World Chinese Medicine,2013,8(1):74-75. |
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| Authors: | Song Mingfu Liu Min |
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| Institution: | ( The Traditional Clinical Chinese Medical Science College of China Three Gorges University, Yichang Municipal Hospital of Traditional Chinese Medicine,Post code: 443000) |
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| Abstract: | Objective：To observe the effect of stasis removing herbs plus RNA-based drugs on TNF- alpha in mice with ulcerative colitis （UC）. Methods： A total of 42 mice with UC, female or masculinity were chosen and divided into three groups, control group, stasis re- moving herbs plus RNA-based drugs group and norfloxacin group. After eight-day observation and treatment, we measured the changes of TNF-α. Results： The stasis removing herbs plus RNA-based drugs group presented obvious therapeutic effect. The level of TNF-α re- duces to the normal level （P 〈 0.01 ）. Conclusion ： Stasis removing herbs plus RNA-based drugs have obvious therapeutic effect on UC, and one of its mechanisms is to reduce the level of TNF-α. |
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| Keywords: | UC TNF-α Stasis removing herbs RNA |
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