老年住院患者临床分离细菌的分布及耐药性

目的 了解华东医院老年住院患者的病原菌分布和耐药性变迁情况,以及与患者的年龄、基础疾病、标本来源的关系.方法 连续监测华东医院近2年老年患者感染的病原菌的分布和耐药性的变迁.从60岁以上老年患者临床标本(痰、血、尿、胆汁、伤口等)中分离病原菌1 266株,其中革兰阴性菌945株,革兰阳性菌321株,对菌株进行鉴定和药敏...

The distribution and drug resistance of clinical bacterial strains from elder inpatients

Objective To understand the distribution of pathogens and their resistance to antibiotics in elder inpatients of Huadong Hospital, as well as the relationship between the patients＇ age, the underlying diseases and the type of specimen resource. Methods The distribution of pathogens in elder inpatients and the change of drug resistance were monitored continuously during the past 2 years. 1 266 strains, including 945 Gram negative strains and 321 Gram positive strains, were isolated from clinical specimens （ sputmn, blood, urine, bile and wound, etc. ） of patients aged above 60 years. All identifications and susceptibilities were determined. The relevant information including patient＇s age, underlying diseases, signs and symptoms pertaining to different infections was collected for statistical analysis. Results Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were the most common pathogens in the elder inpatients. The prevalence of Pseuclomonas aeruginosa was the highest in respiratory system diseases and cardiovascular diseases. The prevalences of Pseudomonas aeruginosa and Escherichia coli were the highest in sputum, urine, wound and bile, etc. The resistance rate of Pseudomonas aeruginosa to cephalosporins, carbapenems, quinolones and aminoglycosides was the highest. The resistance rate of Staphylococcus aureus to levofloxacin and penicillin was the highest. Nevertheless, the resistance rate to vancomycin and linezolid in common Gram positive cocci was nearly zero. Conclusions Bacterial resistance is found to be increasing. It should emphasize on monitoring the relationship of underlying diseases with resistance and resistance mechanism, and it is important to choose the appropriate antibiotics to control infections.