血清胃蛋白酶原、胃泌素-17和幽门螺杆菌IgG抗体对萎缩性胃炎的诊断价值

目的 探讨血清Ⅰ型胃蛋白酶原(PGⅠ)和Ⅱ型胃蛋白酶原(PGⅡ)、胃蛋白酶原(PGⅠ/PGⅡ)比值、胃泌素-17(G-17)和幽门螺杆菌IgG抗体(IgG anti-HP)水平与萎缩性胃炎(AG)发生的关系及其诊断价值.方法 分别采用胶乳免疫比浊法和酶联免疫吸附试验(ELISA)法检测48例AG患者及48名健康对照者血...

The diagnosis value of serum pepsinogen, gastrin-17 and IgG anti-Helicobacter pylori antibody in patients with atrophic gastritis

Objective To investigate the relationship between the serum pepsinogen （PG） Ⅰ , PG Ⅱ, PG Ⅰ/PG Ⅱ ratio, gastrin-17 （G-17）, IgG anti-Helicobacter pylori （IgG anti-HP） antibody and atrophic gastritis （AG） and their diagnostic values. Methods The levels of serum PG Ⅰ , PG Ⅱ , G-17 and IgG anti-HP were detected by emulsion immunoturbidimetry and enzyme-linked immunosorbent assay （ELISA） in 48 patients with AG and 48 healthy subjects as controls. The best cut-off value to screen AG was established according to the receiver operating characteristics （ROC） curve. Results The levels of serum PG Ⅰ, PG Ⅰ/PG Ⅱ ratio and G-17 in the AG group were significantly lower than those in the control group, while the levels of serum PG Ⅱ and IgG anti-HP were significantly higher than those in the control group （P 〈0.01 ）. Serum PGI, PG Ⅱ , PG Ⅰ/PG Ⅱ ratio, G-17 and IgG anti-HP levels in different atrophy regions had statistical significant difference （ P 〈 0.01 ）. According to the ROC curves, the best cut-off values of PG Ⅰ, PG Ⅰ/PG Ⅱ ratio, G-17, IgG anti-HP were 46.7ng/L （ sensitivity 82.4% ,specificity 80.0%, area under curve 0. 831 ± 0. 084）, 4.60 （ sensitivity 94.4%, specificity 85.7%, area under curve 0. 942 ± 0. 041 ）, 7.45 pmol/L （ sensitivity 50.0% ,specificity 72.2% ,area under curve 0.579 ±0. 108） and 78.9 IU （ sensitivity 55.6% ,specificity 85.7% ,area under curve 0.746 ± 0. 089）. Conclusions The detection of serum PG Ⅰ, PG Ⅰ/PG Ⅱ ratio, G-17 and IgG anti-HP levels can be useful to screen AG, and the PG Ⅰ/PG Ⅱ ratio may be the best single parameter for the diagnosis of AG.