开胃进食汤超微配方颗粒对正常小鼠胃肠动力的影响

目的研究开胃进食汤超微配方颗粒对正常小鼠胃排空、小肠推进活动的影响。方法采用开胃进食汤传统汤剂和健胃消食片对照,观察开胃进食汤超微配方的等倍、1/2倍和1/4倍不同剂量对小鼠胃内甲基橙残留率和小肠质量、小肠碳末推进率的影响。结果开胃进食汤超微配方颗粒各组胃内甲基橙残留率较正常组低(P<0.05,P<0.01),等倍和1/2倍剂量组小肠碳末推进率较正常组高(P<0.05,P<0.01),1/2倍剂量组小肠质量较正常组高(P<0.05),而开胃进食汤传统汤剂组与正常组比较,以上指标无差异。结论开胃进食汤超微配方颗粒对正常小鼠具有促进胃肠动力作用,且以1/2倍剂量为优;超微配方颗粒制剂可能与诸相关药物如藿香、木香、丁香等药物挥发油成分作用的关系,从而提高了其传统方剂的药理作用。

Effect of Ultrafine Granules of Kaiwei Jinshi Decoction on Normal Gastric Power in Mice

Objective To study the effects of Kaiwei Jinshi decoction with the ultrafine particle on the normal gastric evacuatian and small intestinal propulsion in mice.Methods The untrafine and traditional decoctions were compared,the methyl orange residual rate in stomach,small intestine weight and small intestine carbon powder propulsion rate were measured with the isodose,1/2 and 1/4 dosages of both ultrafine particle and traditional type.Results The methyl orange residual rate in stomach in all groups of ultrafine particle were lower than that in normal group(P<0.05 or P<0.01),the carbon powder propulsion rate in small intestine with same and 1/2 dosages were higher than that in normal group(P<0.05 or P<0.01),the weight of small intestine with 1/2 dosages was more than that in normal group(P<0.05),while,there was no difference between the traditional herbal medicine and ultrafine particle groups.Conclusion The ultrafine decoction can improve the gastrointestinal power,especially with 1/2 dosages;the ultrafine particle preparation enhances the pharmacological action owing to possibly retaining the component of volatile oil such as Clove,Aucklandiae and Agastache rugosa.