Mediastinal large-cell lymphoma with sclerosis |
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| Authors: | Aldo Scarpa Franco Bonetti Fabio Menestrina Marta Menegazzi Marco Chilosi Maurizio Lestani Chiara Bovolenta Giuseppe Zamboni L. Fiore-Donati |
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| Affiliation: | (1) Istituto di Anatomia e Istologia Patologica, University of Verona, Policlinico Borgo Roma, I-37134 Verona, Italy;(2) Istituto di Chimica Biologica, University of Verona, I-37134 Verona, Italy |
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| Abstract: | Summary The Southern blot hybridization technique has been applied to study the configuration of immunoglobulin and T-cell receptor genes in 6 cases of the so called mediastinal large cell lymphoma with sclerosis. This lymphoma has been recently recognized as a separate entity among non-Hodgkin lymphomas mainly affecting young adult patients. The B-cell origin of this neoplasm was suggested by means of immunohistochemical analysis. However, the immunophenotypical B-cell related markers used do not always exhibit lineage fidelity. The Southern blot analysis demonstrated the presence of unique heavy and k-light chain immunoglobulin gene rearrangements, establishing genotypically their B-cell origin.This work was supported by the Associazione Italiana per la Ricerca sul Cancro, Milano, Italy, and Progetto finalizzato Oncologia (contratto no 86.00461.44), CNR, Rome, Italy. Aldo Scarpa and Maurizio Lestani are supported by a Scholarship from the Associazione Italiana per la Ricerca sul Cancro, Milano, Italy |
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| Keywords: | Mediastinal lymphoma Immunoglobulin deficient B cell lymphoma Gene rearrangement Immunoglobulin genes T cell receptor gene |
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