Metastatic merkel cell carcinoma in the bone marrow of a patient with plasma cell myeloma and therapy-related myelodysplastic syndrome |
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| Authors: | Megan Kielt Kressin Annette S Kim |
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| Affiliation: | 1Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA;2Department of Pathology & Laboratory Medicine, Tennessee Valley Healthcare System Veterans Affairs, Nashville, TN, USA;3Current address: Austin Pathology Associates, 901 W. Ben White Blvd., Austin, TX, USA |
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| Abstract: | Merkel cell carcinoma is an aggressive neoplasm of the skin that shows frequent lymph node metastases, but has only rarely been reported in the bone marrow. Herein we report a case of a 64-year-old male with a history of plasma cell myeloma and recent skin diagnosis of Merkel cell carcinoma who presented for a routine follow-up bone marrow to assess his myeloma. The biopsy showed persistent plasma cell myeloma, trilineage dysplasia, and clusters of neuroendocrine cells consistent with metastatic Merkel cell carcinoma. Discussion of this case, a review of metastatic Merkel cell carcinoma, and identification of clinical settings in which staging bone marrow biopsy may be warranted are presented. |
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| Keywords: | Merkel cell bone marrow metastases plasma cell myeloma |
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