| 654－2对实验性兔脑水肿的保护作用 |
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| 引用本文： | 岳少杰,虞佩兰,杨于嘉,罗自强. 654－2对实验性兔脑水肿的保护作用[J]. 中南大学学报(医学版), 1995, 0(2) |
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| 作者姓名： | 岳少杰 虞佩兰 杨于嘉 罗自强 |
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| 作者单位： | Yue Shaojie; Yu Peilan; Yang Yujian(Department of Pediatrics，Xiangya Hospital，Hunan Medical University)Luo Ziqiang(Department of Physiology，Hunan Medical University) |
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| 摘 要： | 采用兔百日咳杆菌脑水肿模型，观察６５４－２的保护作用，结果发现：兔大脑皮质中脑水含量增高、谷氨酸含量显著下降；６５４－２明显减少实验性脑水肿动物的脑水含量、降低脑组织中谷氨酸含量的下降幅度。提示６５４－２对百日咳杆菌脑水肿具有保护作用，其保护机制可能与抑制脑内谷氨酸的大量释放有关。
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| 关 键 词： | 阿托品衍生物类；654－2；药物作用；百日咳杆菌；脑水肿；疾病模型，动物；谷氨酸盐类；兔 |
PROTECTIVE EFFECT OF 654-2 ON EXPERIMENT BRAIN EDEMA IN RABBITS |
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| Yue Shaojie, Yu Peilan, Yang Yujian. PROTECTIVE EFFECT OF 654-2 ON EXPERIMENT BRAIN EDEMA IN RABBITS[J]. Journal of Central South University. Medical sciences, 1995, 0(2) |
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| Authors: | Yue Shaojie Yu Peilan Yang Yujian |
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| Abstract: | he purpose of this studyis to observe the effect of 654-2 on brain edema model in-duced by pertussis bacilli in rabbits. The results showed that 654-2 declined the water con-tent of brain and increased the glutamate in brain tissue of treatment group compared withgroup without treatment. It suggested that 654-2 had protective effect on brain edema induced by pertussis bacilli.The protective effect of 654-2 was related to inhibition of gluta-mate release from brain tissue. |
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| Keywords: | bordetella pertussis drug effects brain edema disease models ani-mal glutamates atropine derivatives 654-2 rabbits |
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