肝细胞癌尿激酶型纤溶酶原激活物受体mRNA、VEGF和c-erbB2的表达及意义

探讨尿激酶型纤溶酶原激活物受体（UPAR）mRNA、血管内皮细胞生长因子（VEGF）和癌基因c—erbB2在肝细胞癌（HCC）的表达与其病理学特性和肿瘤转移的关系。采用原位杂交方法检测肝细胞癌UPA mRNA表达，免疫组化法检测VEGF和c—erbB2的表达。肝癌转移组的UPAR mRNA、VEGF和c—erbB2阳性表达率及表达强度均明显高于无转移组，二者相比均有显著性差异（P〈0．05），但它们的表达与肝癌的大小、分化程度却无关；UPAR mRNA与VEGF及c—erbB2的表达强度均呈正相关（r=0．656、0．653，P〈0．05）。UPA mRNA、VEGF和c—erbB2的表达可作为肝细胞癌的侵袭表型、判断疗效以及估计预后的重要指标。

Expression and significance of UPAmRNA, VEGF and c - erbB2 in hepatocellular carcinoma

To investigate the expression of urokinase type plasminogen activator receptor(UPAR) mRNA,VEGF and c-erbB2 and to evaluate the relationship between them and pathological properties and metastasis of hepatocellular carcinoma(HCC).The expression of UPAmRNA was detected by in situ hybridization,VEGF and c-erbB2 tested by immunohistochemical assay.The expression rates of UPAR mRNA,VEGF and c-erbB2 tested by immunohistochemical assay.The expression rates of UPAR mRNA,VEGF and c-erbB2 were obviously higher in HCC with metastasis than those in HCC without metastasis(P<0.05).But their expressions were not closely related to tumor size or degree of differentiation.There was a significant relationship between UPAR mRNA,VEGF and c-erbB2 in HCC(r=0.656,0.653,P<0.05).The expression of UPAR mRNA,VEGF and c-erbB2 may be important indexes on evaluating treatment and prognosis of HCC.