The effect of granulocyte colony-stimulating factors on survival parameters in pediatric patients with acute lymphoblastic leukemia: a retrospective study |
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| Affiliation: | 1. Department of Pediatric Hematology and Oncology, Basaksehir Cam ve Sakura City Hospital, Istanbul, Turkey;2. Department of Pediatric Hematology and Oncology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey;1. Department of Pediatrics, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey;2. Department of Pediatric Critical Care Medicine, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey;3. Department of Pediatric Gastroenterology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey;4. INTERGEN Genetic and Rare Diseases Diagnosis Research and Application Center, Ankara, Turkey;5. Department of Pediatric Endocrinology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey;1. Nam?k Kemal University Medical School, Department of Internal Medicine, Division of Hematology, Tekirdag, Turkey;2. Memorial Bahcelievler Hospital Adult Hematology and BMT Clinic, Istanbul, Turkey;3. Yuzuncu Y?l University Medical School, Department of Internal Medicine, Division of Hematology, Van, Turkey;4. Sanko University Medical School, Department of Internal Medicine, Division of Hematology, Gaziantep, Turkey;5. Mugla S?tk? Kocman University Medical School, Department of Internal Medicine, Division of Hematology, Mugla, Turkey;6. Ege University Medical School, Department of Internal Medicine, Division of Hematology, Izmir, Turkey;7. Medicalpark Hospital, Hematology and BMT Clinic, Izmir, Turkey;8. Celal Bayar University Medical School, Department of Internal Medicine, Division of Hematology, Manisa, Turkey;9. Erciyes University Medical School, Department of Internal Medicine, Division of Hematology, Kayseri, Turkey;10. Hacettepe University Medical School, Department of Internal Medicine, Division of Hematology, Ankara, Turkey;11. Ondokuz Mayis University Medical School, Department of Internal Medicine, Division of Hematology, Samsun, Turkey;12. Dicle University Medical School, Department of Internal Medicine, Division of Hematology, Diyarbakir, Turkey;13. Dokuz Eylul University Medical School, Department of Internal Medicine, Division of Hematology, Izmir, Turkey |
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| Abstract: | ObjectiveThere is a paucity of data concerning the use of granulocyte colony-stimulating factors (G-CSFs) in pediatric patients with acute lymphoblastic leukemia (ALL). The aim of the present study was to evaluate the effect of G-CSF use on relapse-free and overall survival in 358 consecutive, newly diagnosed pediatric ALL patients uniformly treated at the same institution between April 2012 and April 2020.Materials and MethodsPatients were evaluated in two separate periods, based on the G-CSF treatment approach. All patients who underwent ALL treatment between April 2012 and December 2016 received G-CSF (G-CSF+ arm; n: 245) in the course of the protocol for reducing the risk of febrile neutropenia and/or inducing neutrophil recovery to prevent any treatment delay. No patients after December 2016 received G-CSF, even if they belonged to the high-risk group, and these were included in the G-CSF? arm (n: 113).ResultsEstimated mean relapse-free (106.5 months; 95 % CI 102?110.8 vs 82 months 95 % CI 75.2?88.9; p: 0.794) and overall survival (111.4 months; 95 % CI 108?114.8 vs 85 months 95 % CI 80.4?89.8; p: 0.431) rates were similar between the G-CSF+ and G-CSF? groups.ConclusionsOur findings indicate that G-CSF use during ALL treatment had no effect on relapse rates or overall survival. |
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| Keywords: | Acute lymphoblastic leukemia Pediatric Colony-stimulating factor Relapse Survival |
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