Acute and chronic pain management in patients with sickle cell disease in the modern era: a comprehensive review |
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| Affiliation: | 1. Department of Transfusion Medicine, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai 410210, India;1. Health Science University, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Department of Pediatric Intensive Care, Turkey;2. Health Science University, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Department of Radiology, Turkey;3. Health Science University, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Department of Pediatrics, Turkey;1. Transfusion Medicine & Blood Centre, Sarvodaya Hospital & Research Centre, Faridabad, Delhi NCR, India;2. Medical Oncology & Hematology, Sarvodaya Hospital & Research Centre, Faridabad, Delhi NCR, India;3. Medical Administration, Sarvodaya Hospital & Research Centre, Faridabad, Delhi NCR, India;1. Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Nursing, School of Medical Sciences, Islamic Azad University, Mashhad Branch, Mashhad, Iran;3. Student of PhD, Department of Pediatric Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran;4. Department of Midwifery, School of Medical Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran |
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| Abstract: | Sickle cell disease (SCD) is the most common inherited red blood cell (RBC) disorder worldwide, resulting in chronic hemolytic anemia, vaso-occlusion, tissue hypoxia, and ultimately end organ damage. The hallmark of the disease is manifested by vaso-occlusive crisis (VOC) resulting in acute on chronic pain, and the most common cause for presentation to the emergency department and hospital admission. The management of pain for patients with SCD in the U.S. has historically been socially and politically complex with most patients experiencing pain on a daily basis but not seeking immediate medical attention. The pathophysiology of acute and chronic pain in SCD is multifactorial and complex. Here, we describe factors contributing to acute and chronic pain in SCD and management strategies. |
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| Keywords: | Sickle cell disease Vaso-occlusive crisis Chronic pain Acute pain Neuropathic pain |
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