右美托咪定联合地佐辛对胫腓骨骨折患者疼痛及应激反应的影响

目的分析右美托咪定联合地佐辛对胫腓骨骨折患者疼痛及应激反应的影响。方法选择2018年8月30日至2019年8月30日在本院骨科确诊的76例胫腓骨骨折患者为研究对象,按照麻醉方式的不同将其分为对照组和试验组,每组38例。对照组使用右美托咪定注射液,试验组在使用右美托咪定注射液基础上加用地佐辛注射液。比较两组患者术前及术后2、8、12、24 h的视觉模拟评分法(VAS)评分、Bruggrmann舒适度评分(BCS)。比较两组患者手术前、后血清应激因子[血糖(BS)、去甲肾上腺素(NE)、肾上腺素(E)及皮质醇(Cor)]水平。结果术后2、8、12、24 h,试验组的VAS评分明显低于对照组,差异具有统计学意义(P<0.05)。术后2、8、12、24 h,试验组患者的BCS评分均显著高于对照组,差异具有统计学意义(P<0.05)。术后,两组患者的BS、NE、E、Cor水平均较术前升高,但试验组低于对照组,差异具有统计学意义(P<0.05)。结论右美托咪定联合地佐辛能有效缓解胫腓骨骨折患者术后疼痛,提高患者的舒适度,降低患者的血清应激因子水平,对患者的恢复有一定的帮助。

Effect of dexmedetomidine combined with dizosin on pain and stress response in patients with tibiofibular fracture

Objective To analyze the effects of dexmedetomidine combined with dizosin on pain and stress response in patients with tibiofibular fracture.Methods Seventy-six patients with tibiofibular fracture confirmed in orthopaedic department of our hospital from August 30,2018 to August 30,2019 were selected as the study objects.According to the different anesthesia methods,the patients were divided into control group and experimental group,with 38 cases in each group.The control group was treated with dexmedetomidine injection,and the experimental group was treated with dizosin injection on the basis of dexmedetomidine injection.The scores of visual analogue scale(VAS)and Bruggermann comfort score(BCS)before and at 2,8,12,24 hours after operation were compared between two groups.The levels of serum stress factors[blood glucose(BS),norepinephrine(NE),epinephrine(E)and cortisol(Cor)]before and after operation were compared between two groups.Results At 2,8,12 and 24 hours after operation,the VAS scores of the experimental group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).At 2,8,12 and 24 hours after operation,the BCS scores of the experimental group were significantly higher than those of the control group,and the differences were statistically significant(P<0.05).After operation,the levels of BS,NE,E and Cor in the two groups were significantly higher than those before operation,but those of the experimental group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion Dexmedetomidine combined with dizosin can effectively relieve the postoperative pain of patients with tibiofibular fracture,improve the comfort of patients,and reduce the levels of serum stress factors,which is helpful for the recovery of patients.