The impact of immediate adverse donation reactions on the return of volunteers undergoing platelet apheresis |
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| Institution: | 1. Departamento de Hematologia, Hemoterapia e Terapia Celular da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil;2. Laboratório de Investigação Médica na Patogênese e Terapia dirigida em Onco-imuno-hematologia (LIM-31), Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil;3. Fundação Pró-Sangue – Hemocentro de São Paulo, São Paulo, SP, Brazil;4. Haematology Department, Churchill Hospital, NHS-BT, Oxford University, Oxford, UK;5. Disciplina de Ciências Médicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil;1. Axencia Galega de Sangue, Órganos e Tecidos (ADOS), Santiago de Compostela (A Coruña), Spain;2. Universitat Autònoma de Barcelona, Spain;3. Hospital Clínico Universitario, Santiago de Compostela (A Coruña), Spain;1. Department of Transfusion Medicine, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai 410210, India;1. Galilee Medical Center, 22100 Nahariya, Israel;2. Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel;1. Galilee Medical Center, 22100 Nahariya, Israel;2. Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel;1. Division of Pediatric Intensive Care, Department of Pediatrics, Ankara City Hospital, Ankara, Turkey;2. Division of Pediatric Neurology, Department of Pediatrics, Ankara City Hospital, Ankara, Turkey;3. Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara City Hospital, Ankara, Turkey;4. Division of Pediatric Genetic, Department of Pediatrics, Ankara City Hospital, Ankara, Turkey;5. Department of Radiology, Ankara City Hospital, Ankara, Turkey;6. Division of Pediatric Hematology, Department of Pediatrics, Ankara City Hospital, Ankara, Turkey;7. Department of Radiology, Hacettepe University, Ankara, Turkey;1. Pediatric Intensivist, Pediatric Intensive Care, University of Health Sciences Turkey, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey;2. Pediatric Neurology, University of Health Sciences Turkey, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey;3. Pediatric Intensivist, Pediatric Intensive Care, University of Health Sciences Turkey, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey;4. Pediatric Intensivist, Chief of the Pediatric Intensive Care Unit, University of Health Sciences Turkey, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey;1. Haematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain;2. Instituto de Investigación Sanitaria (ISS) Hospital La Fe, Valencia, Spain;3. School of Medicine and Dentistry, Catholic University of Valencia, Valencia, Spain;4. CIBERONC, Instituto Carlos III, Madrid, Spain |
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| Abstract: | IntroductionImmediate adverse reactions experienced during donation decrease return rates among whole-blood donors, but little is known about this effect among platelet apheresis donors. We investigated the impact of immediate adverse reactions on the return rates of volunteer apheresis platelet donors.MethodsIn a sample of 4108 consecutive platelet apheresis donors seen from August 2016 through June 2019, we evaluated whether immediate adverse reactions were associated with returning for a subsequent platelet apheresis donation within a 12-month period. We used propensity score matching to compare donors with and without adverse reactions.ResultsAn immediate adverse reaction occurred in 312 (7.6%) donors; 98.5% were mild, and 0.3% were severe. Of the original 4108 platelet apheresis donors, only 3211 (72.3%) returned for a subsequent donation within 12 months. Experiencing an immediate adverse reaction during the donation process significantly decreased the return rate for a subsequent donation HR= 0.74 (0.63–0.87)], especially among female donors HR= 0.70 (0.53–0.93)], donors aged < 30 years HR= 0.71 (0.54–0.94)], with a high school educational level 0.63 (0.49–0.81)], donors donating for the first time HR= 0.73 (0.59–0.90)], and repeat donors with a previous platelet apheresis donation more than 180 days prior HR= 0.68 (0.50–0.93)].ConclusionEven mild adverse events reduce the return rates for a subsequent donation among platelet apheresis donors. Female donors, younger donors, and first-time donors are at higher risk of not returning after an immediate adverse reaction. Preventing the incidence of immediate adverse reactions during platelet apheresis donation may increase the rate of donor retention. |
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| Keywords: | Platelet apheresis Brazil Blood donors Blood componente removal/adverse effects |
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