43例复发脑胶质瘤病理进展的影响因素分析

目的分析低级别脑胶质瘤患者复发术后病理进展为高级别胶质瘤的影响因素。方法收集我院43例复发脑胶质瘤患者的临床资料。利用单因素分析和多因素Logistic回归分析方法分析首发癫痫症状、术前KPS评分、肿瘤IDH类型等因素对复发脑胶质瘤患者术后病理进展的影响。结果43例复发脑胶质瘤患者中,二次手术病理为高级别胶质瘤有9例(20.9%),而无进展者有34例(79.1%)。经单因素分析和多因素Logistic回归分析发现,首发癫痫症状、术后放化疗为影响复发脑胶质瘤患者术后病理进展为高级别胶质瘤的保护性因素(P<0.05)。结论首发癫痫症状和术后放化疗是复发脑胶质瘤病理进展的保护因素。对于非癫痫首发症状或术后未接受放化疗的低级别胶质瘤患者,需密切跟进随访,及早接受合适的临床试验。

Analysis of influencing factors of pathological progression of 43 patients with recurrent glioma

Objective To analyze the influencing factors of postoperative pathological progression to high-grade glioma of recurrent patients with low grade glioma.Methods The clinical data of 43 patients with recurrent glioma in our hospital were collected.Univariate analysis and multivariate Logistic regression analysis were used to analyze the influence of the first epileptic symptom,preoperative KPS score,tumor IDH type and other factors on the postoperative pathological progression of patients with recurrent glioma.Results Among the 43 patients with recurrent glioma,9 cases(20.9%)had high-grade gliomas,while 34 cases(79.1%)had no progression.The univariate analysis and multivariate Logistic regression analysis showed that the first epileptic symptoms and postoperative radiotherapy and chemotherapy were the protective factors for the postoperative pathological progression to high-grade glioma of patients with recurrent glioma(P<0.05).Conclusion The first epileptic symptoms and postoperative radiotherapy and chemotherapy are the protective factors for the pathological progression of recurrent glioma.For low-grade glioma patients without epilepsy as the first symptom or who didn't receive radiotherapy or chemotherapy after operation,follow-up should be followed up closely and appropriate clinical trials should be conducted as soon as possible.