甲状腺素治疗妊娠合并甲状腺功能减退患者的临床效果及对TSH、hs-CRP水平的影响

目的研究甲状腺素治疗妊娠合并甲状腺功能减退患者的临床效果及对促甲状腺激素(TSH)、超敏C-反应蛋白(hs-CRP)水平的影响。方法选取2018年8月30日至2019年8月30日本院妇产科收治的86例妊娠合并甲状腺功能减退患者作为研究对象,采用随机数字分配法将其分为对照组与试验组,各43例。对照组给予常规治疗,试验组在对照组的基础上给予甲状腺素治疗。比较两组患者的治疗效果。结果试验组的治疗总有效率明显高于对照组(P<0.05)。治疗后,试验组的TSH、hs-CRP水平均低于对照组,FT3、FT4水平均高于对照组(P<0.05)。试验组的早产、流产、胎盘剥落及孕妇贫血等妊娠结局情况优于对照组,但差异无统计学意义(P>0.05)。试验组的妊娠高血压、妊娠糖尿病、产后大出血、胎儿异常发生率均低于对照组(P<0.05)。结论甲状腺素治疗妊娠合并甲状腺功能减退患者的临床效果显著,可有效缓解患者甲状腺功能减退的情况,同时还能有效改善TSH、hs-CRP水平,保证胎儿的正常发育,维持孕妇的身体情况,值得临床推广应用。

Clinical effect of thyroxine in the treatment of pregnant women with hypothyroidism and its influence on TSH and hs-CRP levels

Objective To study the clinical effect of thyroxine in the treatment of pregnant women with hypothyroidism and its influence on thyroid stimulating hormone(TSH)and high sensitivity C-reactive protein(hs-CRP)levels.Methods A total of 86 pregnant women with hypothyroidism from August 30,2018 to August 30,2019 in the gynecology and obstetrics department of our hospital were selected as the study objects.The patients were divided into control group and experimental group according to random number distribution method,with 43 cases in each group.The control group was given routine treatment,and the experimental group was given thyroxine treatment on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the experimental group was significantly higher than that in the control group(P<0.05).After treatment,the levels of TSH and hs-CRP in the experimental group were lower than those in the control group,and the levels of FT3 and FT4 were higher than those in the control group(P<0.05).The pregnancy outcomes of preterm delivery,abortion,placental exfoliation and anemia of pregnant women in the experimental group were better than those in the control group,but the differences were not statistically significant(P>0.05).The incidences of pregnancy hypertension,pregnancy diabetes,postpartum hemorrhage and fetal abnormality in the experimental group were lower than those in the control group(P<0.05).Conclusion Thyroxine in the treatment of pregnant women with hypothyroidism has significant clinical effect,it can effectively alleviate the hypothyroidism of the patients,at the same time,improve TSH and hs-CRP levels,ensure the normal development of the fetus,and maintain the physical condition of pregnant women,which is worthy of clinical promotion and application.