Adverse events of red blood cell transfusions in patients with sickle cell disease |
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| Affiliation: | 1. Children’s Healthcare of Atlanta, Department of Pathology and Laboratory Medicine, 1405 Clifton Rd NE, 1st Floor, Atlanta, GA 30322, USA;2. Emory University School of Medicine, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, 1405 Clifton Rd NE, Atlanta, GA 30322, USA;3. The Children’s Hospital of Philadelphia, Departments of Pediatrics and Pathology and Laboratory Medicine, The School of Medicine at the University of Pennsylvania, 3615 Civic Center Boulevard, Abramson Research Building Room 316D, Philadelphia, PA 19104, USA;1. Galilee Medical Center, 22100 Nahariya, Israel;2. Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel;1. Galilee Medical Center, 22100 Nahariya, Israel;2. Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel;1. Haematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain;2. Instituto de Investigación Sanitaria (ISS) Hospital La Fe, Valencia, Spain;3. School of Medicine and Dentistry, Catholic University of Valencia, Valencia, Spain;4. CIBERONC, Instituto Carlos III, Madrid, Spain;1. Servizio di Immunoematologia e Medicina Trasfusionale, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy;2. Bone Marrow Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy |
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| Abstract: | Blood transfusion is a common medical intervention for patients with sickle cell disease (SCD) and disease related complications. While patients with SCD are at risk for all transfusion related adverse events defined by the National Healthcare Safety Network (NHSN) Biovigilance Component Hemovigilance Module Surveillance Protocol, they are uniquely susceptible to certain adverse events. This review discusses risk factors, mitigation strategies, and management recommendations for alloimmunization, hemolytic transfusion reactions, hyperviscosity and transfusion-associated iron overload in the context of SCD. |
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| Keywords: | Transfusion Sickle cell disease Alloimmunization Hemolytic Reaction Iron overload |
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