Deferral due to low hemoglobin and predictors of permanence in the blood donation system of repeat female blood donors |
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| Affiliation: | 1. Universidad del Rosario, Escuela de Medicina y Ciencias de la Salud, Carrera 24 #63C-69, Quinta Mutis, Bogotá, D.C., Colombia;2. Fundación Universitaria del Area Andina, Facultad de Ciencias de la Salud y el Deporte, Calle 69 #15-40, Bogotá, Colombia;3. Banco Nacional de Sangre, Cruz Roja Colombiana, Av Carrera 68 #68B-31, Bogotá, D.C., Colombia;4. FUATS, Carrera 70 #120-99, Bogotá, D.C., Colombia;5. German RC Blood Services, Working Group of the GRC, Am Mühlberg 14 B Starnberg, D- 82319, Germany;1. Division for Metabolic Diseases, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia;2. Department of Clinical Nutrition, University Hospital Centre Zagreb, Zagreb, Croatia;3. Division of Clinical Pharmacology, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia;4. Department of Neurology, University Hospital Centre Zagreb, Zagreb School of Medicine University of Zagreb, Zagreb, Croatia;5. Division for Arterial Hypertension, Nephrology, Dialysis and Transplantation, Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia;1. Department of Medicine, McMaster University, Hamilton, Ontario, Canada;2. Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada;1. Department of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Sq., 917798564, Mashhad, Iran;2. Neonatal Research Center, Mashhad University of Medical Sciences, Neonatal Intensive Care Unit, Imam Reza Hospital, 9177899191, Mashhad, Iran;3. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Azadi Sq., 917798564, Mashhad, Iran;1. Department of Environmental Health, National Institute of Public Health, 351-0197, Wako, Japan;2. Hiroshima High-Precision Radiotherapy Cancer Center, 732-0057, Hiroshima, Japan;3. Department of Radiation Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 734-8551, Hiroshima, Japan |
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| Abstract: | ObjectivesTo evaluate the deferral rate due to low hemoglobin (Hb) in repeat female blood donors and identify the factors affecting their permanence in the blood donation system.Materials and methods8,368 repeat female blood donors who donated from January 2012 to December 2018 were included. Bivariate analysis and Kaplan-Meier curves were used to identify the covariates possibly associated with developing low Hb, and Cox proportional hazards modeling was used to adjust for all confounders.ResultsThe global deferral rate due to low Hb was 2.4 %. According to baseline Hb, the frequency of low Hb was 0.7–4.1 %, and it was higher in platelet donors (5.8–9.1 %) than in whole blood donors (1.9 %). The main predictors were baseline Hb (compared to the first quartile; hazard ratio [HR] = 0.487 for the second quartile; 0.234 for the third; and 0.095 for the fourth); change in Hb (HR = 2.689 for a >0.49 g/dL change, compared to smaller changes); the type of donation (compared to whole blood donors, HR = 2.317 for platelet donors); and donation interval (compared to >12.5 month intervals; HR = 2.220 for 8.0?12.5 months; HR = 5.658 for 5.4?8.0 months; and HR = 9.452 for <5.4 months).ConclusionsIn female blood donors at moderate altitude, the probability of developing low Hb increases with a baseline Hb of 13.5?14.0 g/dL, with a change in Hb >0.49 g/dL, in platelet donors, and with donation intervals <12.5 months. These four predictive factors can be used together for early identification of donors at risk of developing low Hb, to institute appropriate measures. |
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| Keywords: | Blood donation Anemia Hemoglobinometry Cox proportional hazards model |
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