剖宫产术后应用地佐辛静脉镇痛的临床效果及对新生儿的影响

目的探讨剖宫产术后应用地佐辛静脉镇痛的效果及对新生儿的影响。方法选取我院收治的90例剖宫产术产妇作为研究对象,按照掷骰子法将其分为研究组与对照组,每组45例。两组均于腰-硬联合麻醉下行剖宫产术,手术后即刻连接PCIA泵,研究组PCIA泵配方为地佐辛注射液(0.5 mg/kg)与盐酸托烷司琼注射液(10 mg),对照组PCIA泵配方为盐酸纳布啡注射液(2 mg/kg)与盐酸托烷司琼注射液(10 mg)。比较两组产妇的VAS、Ramsay评分、泌乳素水平、产妇首次下床活动时间、新生儿情况及产妇术后不良反应发生情况。结果术后2、6、12、24、48 h,研究组产妇的VAS评分均低于对照组(P<0.05)。术后6、12、24 h,研究组产妇的Ramsay评分均低于对照组(P<0.05)。术后24 h,两组产妇的泌乳素水平均升高,且研究组高于对照组(P<0.05)。研究组产妇的首次下床活动时间短于对照组(P<0.05)。术后12 h,研究组新生儿NBNA评分明显高于对照组(P<0.05)。两组产妇的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论剖宫产术后应用地佐辛静脉镇痛的效果显著,且对新生儿的影响较小,值得临床推广应用。

Clinical effect of intravenous analgesia with dezocine after cesarean section and its influence on neonates

Objective To explore the effect of intravenous analgesia with dezocine after cesarean section and its influence on neonates.Methods A total of 90 cases of parturients undergoing cesarean section in our hospital were selected as the research objects.The parturients were divided into research group and control group according to the dice rolling method,with 45 cases in each group.Both groups were given cesarean section under combined spinal and epidural anesthesia,and PCIA pump was connected immediately after operation.The PCIA pump formulation of the research group was dezocine injection(0.5 mg/kg)and tropisetron hydrochloride injection(10 mg),the PCIA pump formulation of the control group was nalbuphine hydrochloride injection(2 mg/kg)and tropisetron hydrochloride injection(10 mg).The scores of VAS,Ramsay,levels of prolactin concentration,the first time of getting out of bed activity of parturients,neonates condition and incidences of adverse reactions of parturients after surgery were compared between the two groups.Results At 2,6,12,24 and 48 hours after operation,the VAS scores in the research group were lower than those in the control group(P<0.05).At 6,12 and 24 hours after operation,the Ramsay scores in the research group were lower than those in the control group(P<0.05).At 24 hours after operation,the levels of prolactin in the two groups increased,and that in the research group was higher than the control group(P<0.05).The first time of getting out of bed activity in the research group was shorter than that in the control group(P<0.05).At 12 hours after operation,the NBNA score of neonates in the research group was significantly higher than that in the control group(P<0.05).There was no significant difference in the total incidences of adverse reactions between the two groups(P>0.05).Conclusion Intravenous analgesia with dezocine after cesarean section has a significant effect,and has less impact on neonates.It is worthy of clinical promotion and application.