Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents |
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| Authors: | Almerico Anna Maria Mingoia Francesco Diana Patrizia Barraja Paola Montalbano Alessandra Lauria Antonino Loddo Roberta Sanna Laura Delpiano Donatella Setzu Maria Giovanna Musiu Chiara |
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| Institution: | Dipartimento Farmacochimico, Tossicologico e Biologico, Universita' degli Studi, Via Archirafi 32-90123, Palermo, Italy. almerico@unipa.it |
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| Abstract: | The pyrrolo1,2-f]phenanthridines 8-22 and the corresponding non-rigid analogues 23-41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16-18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition. |
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