Involvement of chromosome 9 in variant Ph1 translocation |
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| Authors: | C R Bartram B Anger F Carbonell E Kleihauer |
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| Affiliation: | 1. Departments of Pediatrics II, University of Ulm, 7900 Ulm, Federal Republic of Germany;2. Internal Medicine III, University of Ulm, 7900 Ulm, Federal Republic of Germany;3. Clinical Physiology, University of Ulm, 7900 Ulm, Federal Republic of Germany |
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| Abstract: | Cytogenetic analysis of a patient with chronic myelocytic leukemia revealed a translocation (21; 22) (q 22; q 11) without a detectable involvement of chromosome 9. By in-situ hybridization studies, however, we demonstrate a reciprocal translocation of sequences from chromosome 9 (c-abl) to Ph1 and chromosome 22 (bcr) to 9, respectively. These observations suggest a consistent participation of chromosome 9 in the Ph1 translocation, regardless of the cytogenetic subtype. |
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| Keywords: | Chronic myelocytic leukemia Philadelphia translocation chronic myelocytic leukemia Philadelphia chromosome breakpoint cluster region cellular homologue of the oncogene detected in Abelson murine leukemia virus |
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