抵抗素基因+299G/A多态性与T2DM并高血压病的相关性

目的研究抵抗素基因＋299G／A多态性与中国北方地区汉族人群2型糖尿病（T2DM）并高血压病的关系。方法采用聚合酶链式反应-限制性片段长度多态性技术检测北方地区汉族人群261例T2DM患者的抵抗素基因内含子2区299G／A突变。结果T2DM组GG、GA、AA基因型及G／A等位基因频率与非T2DM组比较有显著统计学差异（P〈0．01）；T2DM组GG基因型携带者空腹血糖明显高于AA基因型携带者（P〈0．05）。多元线性逐步回归分析显示，抵抗素基因＋299G／A与收缩压、舒张压无明显相关性。结论抵抗素基因＋299G／A多态性与T2DM有关．与高血压病元明显相关性。

Correlation of resistin gene +299G/A polymorphism with type 2 diabetes with hypertension

Objective] To investigate the relationship between resistin gene +299G/A polymorphism and type 2 diabetes with hypertension in Han Chinese of the North.Methods] The genotypes of +299G/A variant in resistin gene intron 2 were determined with polymerase chain reaction-restriction fragment length polymorphism assay(PCR-RFLP)of 261 subjects in Han Chinese of the North.Results] There were significant differences of GG,GA,AA genotypes and G/A alleles frequencies between patients with Type 2 diabetes and nondiabetic subjects(P<0.01).Fasting plasma glucose was increased significantly in the GG subjects compared with AA subjects(P<0.05).Multiple linear stepwise regression indicated there was no obvious correlation between resistin gene +299G/A and systolic blood pressure,diastolic blood pressure.Conclusion] There is a correlation between resistin gene +299G/A polymorphism and type 2 diabetes,but no obvious correlation with hypertension.