丘脑底核电刺激术治疗原发性肌张力障碍

目的观察双侧丘脑底核(STN)脑深部电刺激(DBS)治疗原发性肌张力障碍的疗效。方法回顾性分析8例接受双侧STN-DBS的原发性肌张力障碍病人的临床资料。分别在术前和术后1、3、6个月进行Burke-Fahn-Marsden肌张力障碍评分(BFMDRS)和帕金森病综合评分量表(UPDRS),计算两项评分改善率,评价治疗效果。结果 BFMDRS和UPDRS评分的改善率:术后1个月其均值分别为47%和48%,术后3个月为69%和73%,术后6个月为75%和79%。结论 STN-DBS可有效改善原发性肌张力障碍病人的症状,术后疗效稳定。STN是DBS治疗原发性肌张力障碍的理想靶点。

Subthaiamic nucleus deep brain stimulation for the treatment of primary dystonia

Objective To observe therapeutic effect of bilateral subthalamic nucleus （STN） deep brain stimulation （DBS） for primary dystonia. Methods Clinical data of 8 primary dystonia patients undergoing bilateral STN-DBS were analyzed retrospectively. The Burke-Fahn-Marsden Dystonia Rating Scale （BFMDRS） and Unified Parkinson＇s Disease Rating Scale （UPDRS） were recorded preoperatively and 1, 3 and 6 months after the operation, and the improvement rates of the scores were calculated to evaluate the treatment outcomes. Results The mean improvement rates of BFMDRS and UPDRS scores were 47% and 48% 1 month after operation, 69% and 73% 3 months after operation, 75% and 79% 6 months after operation respectively. Conclusions STN-DBS can effectively improve the symptoms of patients with primary dystonia, and the therapeutic effect is stable. STN is an ideal target of DBS treatment for patients with primary dystonia.