家兔单侧岩静脉离断模型的建立及其解剖基础

目的 建立一种稳定的单侧岩静脉离断动物模型.方法 家兔16只,其中用于制作尸头硅胶灌注标本6只,观察家兔颅后窝静脉引流特点,并与人静脉引流情况比较;另外10只模拟神经外科手术入路,在显微镜下电凝并切断岩静脉,建立单侧岩静脉离断动物模型.结果 在硅橡胶灌注的6具兔头标本中,有1具仅灌出动脉,其余兔尸头灌注情况均较满意.用于制作岩静脉单侧离断模型的10只家兔中,建模成功8只,失败2只.结论 开颅电凝切断家兔岩静脉建立单侧岩静脉离断动物模型是可行的.

Establishment of animal model of unilateral petrosal vein disconnection and its anatomic basis in rabbits

Objective To establish a stable animal model of unilateral petrosal vein disconnection. Methods Sixteen rabbits were randomly divided into 2 groups. The cadaver head specimens were made by infusion of silicone rubber in 6 rabbits to observe the characteristics of vein drainage in the posterior cranial fossa in rabbits, and compared them with human situation of vein drainage. The other 10 rabbits were cut of unilateral petrosal vein with electric coagulation under microscope via a simulated neurosurgical approach for establishing the animal model of unilateral petrosal vein disconnection. Results Among the 6 cadaver head specimens, 1 showed only the artery infusion and the Others were infused well. Among the 10 rabbits used to establish the animal model of unilateral petrosal vein mutilation, the modeling was successful in 8 and failed in 2. Conclusions The establishment of animal model of unilateral petrosal vein disconnection by craniotomy with electric coagulation of the vessel in rabbit is feasible.