中国人群WRN基因多态性与脑膜瘤的关联研究

目的探讨Werner(WRN)基因与中国人群脑膜瘤发病风险的关联。方法对215例病理确诊的脑膜瘤病人和219例健康人,采用Snapshot方法对4个多态性位点(rs3024239、rs2725364、rs1800392、rs1801195)进行基因分型,比较脑膜瘤与健康人群之间WRN基因不同位点基因频率分布差异,并根据性别、年龄及病理亚型进行分层分析。结果 rs3024239多态性位点与内皮型脑膜瘤发病关联,rs3024239位点携带等位基因C的人群内皮型脑膜瘤的发病风险较低(P=0.015)。余3个位点多态性与脑膜瘤无明显相关性(均P>0.05);4个位点基因多态性与不同年龄与性别的脑膜瘤人群的发病风险无明显相关(均P>0.05)。结论中国人群中WRN基因多态性可能与脑膜瘤的发病风险具有相关性,rs3024239位点等位基因C能降低内皮型脑膜瘤的发病风险。

Association study between polymorphism of WRN gene and meningioma in Chinese population

Objective To explore the association of Werner （WRN） gene with the risk of intracranial meningioma in Chinese population. Methods Two hundred and fifteen patients with intracmnial meningioma diagnosed by pathological examination and 219 healthy individuals were recruited in this study. The genotype of 4 polymorphic loci （rs3024239, rs2725364, rs1800192, rs 1801195） of WRN gene was studied by Snapshot method. The frequency distribution of different loci of WRN gene was compared between meningioma patients and healthy individuals, and stratified analysis was also conducted according to gender, age and pathological subtypes. Results The polymorphic locus of rs3024239 was significantly associated with endothelial type of meningioma and the population with allele C in rs3024239 had lower risk of endothelial type of meningioma （P=0.015）, while the genetic polymorphisms of the other 3 loci had no significant correlation with meningioma （all P〉0.05）. There was no obvious correlation between genetic polymorphism of the 4 loci and risk of meningioma in population with different ages and genders （all P〉0.05）. Conclusions The genetic polymorphism of WRN gene may correlate with the risk of intracranial meningioma, and the allele C of rs3024239 can decline the risk of endothelial type ofmeningioma in Chinese population.