定君生胶囊用于妊娠期细菌性阴道病的临床观察

目的调查妊娠期细菌性阴道病(BV)的发病情况,观察定君生胶囊治疗细菌性阴道病的有效性。方法采用珠海市银科生物技术应用研究所生产的细菌性阴道病快速检测卡,对不同孕周的1500名孕妇进行BV筛查,确定妊娠期细菌性阴道病的发病率。对确诊为BV的孕妇266例,随机分为两组。定君生组:136例,给予定君生胶囊(乳杆菌活菌胶囊)阴道给药治疗;孚舒达组:130例,给予孚舒达栓(复方甲硝唑栓)阴道给药治疗。两组均连续用药10d,停药7d后复查。结果妊娠期BV的检出率为17.73%。定君生胶囊治疗BV的总有效率为92.65%,孚舒达栓治疗BV的总有效率为91.53%,二者差异无显著性(P>0.5)。结论妊娠期BV的发病率较高。定君生胶囊能有效改善阴道内生态环境,治疗妊娠期细菌性阴道病安全、有效,易为孕妇所接受。

Clinical surgery of living preparation of lactobacillus in treatment for bacterial vaginosis

Objective:To investigate the prevalence of bacterial vagiosis(BV) in pregnant women and evaluate the efficacy of living preparation of lactobacillus in the treatment of pregnant women with BV.Methods:A total of 1500 pregnant women at different gestational weeks underwent BV screening and 266 patients were diagnosed with BV.All the 266 patients were allocated into two groups randomly;136 patients were treated by Living Preparation of Lactobacillus and 130 cases by Compound Metronidazole Suppository for 10 days continuously.Results:The prevalence of BV in pregnant women was 17.73%.The response rate of living preparation of lactobacillus in the treatment of pregnant women with BV was 92.65%,and the response rate of Metronidazole was 91.53%,there was no significantly different in two groups(P>0.5).Conclusions:A high incidence of BV occurs in pregnant women.Living cells of Lactobacillus are normal physiological bacteria group in healthy women vagina.It metabolic products are lactic acid and hydroperoxide,which can keep acidic environment of vagina and clear and restrain harmful bacteria from growing is efficacious and safest for treatment of BV during pregnancy and easy to be received by the pregnant women with bacterial vagiosis.