丁基苯酞对血管性痴呆患者自由基及血液流变学的影响

目的研究丁基苯酞对血管性痴呆患者脑血流动力学及对神经功能的影响。方法将80例血管性痴呆患者按病情相匹配的原则分为治疗组46例,对照组34例,治疗组采用常规内科治疗和丁基苯酞治疗20d,对照组采用常规内科治疗20d,治疗前及治疗后4周行脑血流动力学检查、日常生活活动能力(ADL)量表测定、听觉P300测试。结果治疗后脑血流动力学检查ADL量表测定、听觉P300测试组间比较有显著性差异(P<0.05或P<0.01)。结论丁基苯酞能改善血管性痴呆患者脑血流动力学,促进神经功能康复。

Effect of butylphthalide soft capsules on free radical and hemorheology of vascular dementia patients

Objective To study the effect of Butylphthalide soft capsules on vascular dementia patients of free radical and hemorheology.Methods Sixty cases of vascular dementia patients were chosen.One hundred and twenty cases of healthy old men were chosen,including 60 cases in control group and 60 cases in health group.The activity changes of peroxide dismutase(SOD),perxide lipid(LPO),malondialdehde(MDA) and glutathione peroxidase(GSH-PX) in blood serum and hemorheology markers were observed before and after the therapy.Results After the therapy,the activity of SOD and GSH-PX increased,and MDA and LPO declined(P <0.05).Hemorheology markers were obviously improved.Conclusion Butylphthalide soft capsule has the effect of resisting the damage of MDA,LPO and other free radicals,and activating SOD and MDA.It can dramatically decrease TC,TG,LDLC,and enhance HDL and improve the abnormal marker in hemorheology.