"一站式"复合(Hybrid)技术治疗冠状动脉多支病变35例

目的 总结"一站式"复合("Hybrid")技术治疗冠状动脉多支病变经验,探讨其临床应用价值.方法 2007年6月至2008年5月,35例冠心病病人在"一站式"复合手术室内接受治疗.冠状动脉病变平均2.5支/例.左心室射血分数0.62±0.07.经胸骨下端小切口在不停跳状态下行左乳内动脉(LIMA)至前降支(LAD)旁路移植术.即刻冠状动脉造影证实LIMA-LAD通畅后同期对其他冠状动脉病变靶血管行经皮冠状动脉介入治疗(PCI).结果 住院期间无出血再次开胸、卒中、围术期心梗、急性肾功能衰竭或死亡等发生.全组34例顺利行"一站式"复合手术,旁路移植后即刻冠状动脉造影示吻合u通畅,LAD血运重建满意.1例PCI时因钝缘支夹层转为体外循环下冠状动脉旁路移植术(CABG).全组PCI治疗冠状动脉病变61处,其中6处病变行单纯球囊扩张冠状动脉成形术,其余部位病变置入药物洗脱支架,共62枚,平均1.8枚/例,置入支架的平均直径为(3.2±0.5)mm,每例病人支架的平均长度为37.3 mm.顺利进行"一站式"复合手术的34例病人呼吸机辅助平均(10.8±7.9)h,其中4例在术后即刻于手术室拔除气管插管;ICU滞留平均(33.6±33.0)h;24例病人未使用血液制品;术后恢复顺利.平均(9±3)天出院.结论 "一站式"复合技术治疗冠状动脉多支病变安全町行,尤其对合并高危因素病例安全有效.

"One-slop" hybrid approach for multi-vessel coronary artery disease in 35 patients

Objective To summarize the clinical experience of "One-stop" hybrid procedure that performs minimally in-vasive direct coronary artery bypass ( MII)CAB ) and percutaneous coronary intervention ( PC! ) concurrently on 35 patients with multivessel coronary artery disease (CAD). Methods Between June 2007 and May 2008, 35 patients 33 men and 2women, mean age (63.5±9.2) years] with multivessel CAD ( two-vessel CAD, n = 19; three-vessel CAD, n = 16, left main coronary artery disease, n = 7 ; coronary artery lesions, 2.5 lesions per patient) underwent "one-stop" hybrid procedure. The hybrid strategy was performed as a primary MIDCAB procedure for bypassing the left internal mammary artery ( LIMA ) to the left anterior descending artery ( LAD ), simultaneously followed by PCI ( pereutaneous transluminal coronary angioplasty (PTCA) and/or stenting) on the remaining non-LAD vessels. Concomitant diseases included hypertention in 20 patients, hy-perlipemia in 12 patients, previous myocardial infarction (MI) in 10 patients, diabetes mellitus (type 2) in 9 patients, previ-ous cerebrovascular disease in 2 patients, chronic obstructive pulmonary disease (COPD) in 1 patient, renal dysfunction in 1 patient, and ostium secundum atrial septal defect in 1 patient. The left ventricular ejection fraction (LVEF) averaged 0. 62±0.07. Results There were no reexploration for bleeding, strokes, myocardial infarctions, acute renal dysfunctions, or deaths in hospetal. Of the total 35 patients, 34 patients (97.1%) were successfully treated with "one-stop" hybrid procedure, and 1 patient (2.9%) was converted to conventional coronary artery bypass grafting ( CABG ) because of dissection of one obtuse marginal branch during PCI. One of the LIMA-LAD grafts was confirmed to be anastomotic stenosis by followed coronary angiog-raphy and was corrected immediately. The patient with ostium secundum defer underwent tranesophageal echocardiography guiding transcatheter closure after LIMA-LAD anastomosis. Catheter-based interventions were carried out in 61 coronary le-sions, including PTCA in 6 lesions and implantation of 62 drug-elating stents (DES) in the rest appropriate lesions. The mean number of DES implantation was 1.8 per patient, and the average diameter and length of implanted DES were respectively ( 3.2±0.5 )mm and 37.3 mm per patient. Of the 34 patients receiving hybrid procedure, the average mechanical ventrilation time was ( 10.8±7.9) hours, and 4 ( 11. 8% ) pateints were extubated in the operating room; length of stay in the intencive care unit averaged (33.6±33.0) hours and hospital stay (9±3) days; 24 patients (70.6%) avoided transfusion require-ment. Conclusion Our findings indicate that in high-risk patients with multivessel CAD, the "one-stop" hybrid procedure by performing MIDCAB and PCI simultaneously is a feasible and safe alternative.