慢性阻塞性肺疾病患者C反应蛋白水平变化及其临床意义

目的:探讨C反应蛋白(C reactive protein,CRP)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)不同时期的水平变化及其临床应用价值。方法:检测64例COPD急性加重期患者(AECOPD)与62例缓解期患者的血清CRP水平、白细胞计数(WBC)及中性粒细胞比值(NE%)。结果:AECOPD患者CRP为(53.8±15.3)mg/L,缓解期为(6.4±5.8)mg/L,差异有统计学意义(P<0.01);AECOPD患者CRP阳性率为96.88%,显著高于WBC和NE%的阳性率(P<0.01和P<0.05)。结论:COPD患者CRP值在急性加重期明显升高,血清CRP水平是AECOPD诊断的优选指标。

Changes of the level of C reactive protein in patients with chronic obstructive pulmonary disease and its clinical significance

Objective：To observe C-reactive protein （CRP） level variation in patients with chronic obstructive pulmonary disease （COPD） and to investigate its clinical significance. Methods：The serum CRP level of 64 patients with COPD at acute exacerbation （AECOPD） and 62 patients at stable stage was measured, and the white blood cells （WBC） and percentage of neutrophils （NE%） were also collected. Results ： The serum CRP level of AECOPD patients （ 53.8 ± 15.3 ） mg/L was significantly higher than that of the patients at the stable stage （ 6.4 ± 5.8 ） mg/L （ P 〈 0.01 ） ; the positive rate of the serum CRP of AECOPD patients was significantly higher （96.88%） than that of WBC （ P 〈 0.01 ） and NE% （ P 〈 0.05 ）. Conclusions： The serum CRP level of COPD patients increases significantly at the acute exacerbation stage and it is a preferential index in diagnosis of AECOPD.