MOLECULAR GENETICS OF THE SA GENE |
| |
| Authors: | Naoharu Iwai Tadashi Inagami Masahiko Kinoshita |
| |
| Institution: | 1st Department of Internal Medicine, Shiga University of Medical Sciences, Tsukinowa Seta, Ohtsu-city, Shiga-ken, Japan and;*Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, USA |
| |
| Abstract: | 1. We have recently identified a candidate gene for rat genetic hypertension, termed Sa, by identifying an mRN A species that shows markedly higher expression in the kidneys of spontaneously hypertensive rats (SHR) than in those of Wistar-Kyoto rats (WKY). 2. Subsequent genetic co-segregation analyses by ourselves and others indicated that the Sa gene locus did indeed influence blood pressure. Moreover, in a preliminary association study, we found an association of a polymorphism of the human Sa gene with essential hypertension. 3. Further studies to identify functions of the Sa gene products are required before reaching a definite conclusion. |
| |
| Keywords: | |
|
|
