胫骨超声速率与两种骨密度测定方法的比较

目的研究国际新近发展的胫骨超声速率（ＳＯＳ）与双能Ｘ线吸收法（ＤＥＸＡ）及单光子吸收法（ＳＰＡ）测定的骨密度（ＢＭＤ）的相关性。方法对２１３名年龄２２－８３岁（平均５４．３±１５．２岁）的女性健康志愿者及５６例年龄５３－８３岁（平均６７．９±７．４岁）的原发性骨质疏松症椎体骨折患者进行胫骨ＳＯＳ及ＤＥＸＡ、ＳＰＡ骨密度测定。结果２１３名健康志愿者的胫骨ＳＯＳ值与ＤＥＸＡ测定的４个部位ＢＭＤ值和ＳＰＡ测定的２个部位的ＢＭＤ值呈显著的正相关〔Ｐ＜０．００１）;选取１０４名年龄、绝经年限及体重指数与骨折组,相匹配的健康志愿者（平均年龄６６．９±６．１岁）作为对照组,与椎体骨折组进行比较两组之间的胫骨ＳＯＳ值有显著差别（Ｐ＜０．０１）。结论胫骨ＳＯＳ与ＤＥＸＡ及ＳＰＡ测定的６个部位的ＢＭＤ值有非常显著的正相关;胫骨ＳＯＳ在椎体骨祈组与对照组之间有显著差别。

Ultrasound bone measurement of the tibia: comparison with vertebral dual-energy X-ray absorptiometry and appendicular single photon absorptiometry

OBJECTIVE: Ultrasonic techniques have been used to assess the mechanical properties of bone. Recently, a new ultrasonic bone instrument, which measured the SOS (speed of sound) at the tibial shaft, has been introduced (Sound Scan 2000, Myriad Ultrasound Systems Ltd.). The aim of this work was to investigate the correlation of tibial SOS with bone mineral density (BMD). METHODS: The tibial SOS was measured in 213 healthy women (aged 22-83 years) and 56 female primary osteoporosis with vertebral fractures (aged 53-82 years). Values of SOS were compared with BMD assessed by dual energy x-ray absorptiometry (DEXA) at spine and hip sites and single photon absorptiometry (SPA) at the distal forearm. RESULTS: Tibial SOS correlated more closely with the BMD of lumbar, hip and forearm (r = 0.387-0.928, P < 0.001). The tibia SOS values and the BMD values measured by the DEXA and SPA were negatively correlated to age and years since menopause. In particular, they were obviously lower in the group of 50 years old. The tibial SOS of vertebral fracture group was significantly lower than that of well-matched non-fracture-group (n = 104, aged 51-84 years). CONCLUSIONS: Tibial SOS was significantly correlated with BMD measured by DEXA or SPA respectively and able to discriminate patients with vertebral fracture from the age-matched controls.