| 喉咽清水蜜丸的研制及其药效学和毒理学研究 |
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| 引用本文： | 张一飞,曲福军,吴琳华,邱晓红.喉咽清水蜜丸的研制及其药效学和毒理学研究[J].中国药房,2004,15(2):78-80. |
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| 作者姓名： | 张一飞 曲福军 吴琳华 邱晓红 |
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| 作者单位： | 1. 哈尔滨医科大学附属第二医院临床药学药物研究所,哈尔滨市,150086
2. 哈尔滨市公安医院,哈尔滨市,150001 |
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| 基金项目： | 黑龙江省科技厅科技攻关项目 |
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| 摘 要： | 目的 :研究喉咽清水蜜丸的制备、质量控制方法及其药效学和毒理学。方法 :采用高效液相色谱法测定喉咽清水蜜丸中甘草酸的含量 ;对制剂的抗炎、镇痛、祛痰作用进行研究 ;对制剂的急性毒性和长期毒性进行研究。结果 :喉咽清水蜜丸中甘草酸的线性范围为0 0384～0 615mg/ml ,回收率为 (99 20±1 75) %。本制剂具有抗炎、镇痛、祛痰作用 ,未见明显急性毒性和长期毒性。结论 :本制剂制备工艺简单 ,质量可控 ,疗效确切 ,安全性较高。
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| 关 键 词： | 喉咽清水蜜丸 甘草酸 药效学 毒理学 |
| 文章编号： | 1001-0408(2004)02-0078-03 |
| 修稿时间： | 2003年2月8日 |
Preparation,Pharmacodynamics and Toxicology of Houyanqingshui Honeyed Pills |
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| ZHANG Yifei,QU Fujun,WU Linhua.Preparation,Pharmacodynamics and Toxicology of Houyanqingshui Honeyed Pills[J].China Pharmacy,2004,15(2):78-80. |
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| Authors: | ZHANG Yifei QU Fujun WU Linhua |
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| Abstract: | OBJECTIVE:To study the preparation,quality control,pharmacodynamics and toxicology of Houyanqingshui honeyed pills(HHP).METHODS:The content of glycyrrhizic acid in HHP was determined with HPLC;the anti-inflammatoˉry,analgesic and expectorant actions of this preparation and the acute and long-term toxicity were observed.RESULTS:The linear range of glycyrrhizic acid in HHP was0.0384～0.615mg/ml.The recovery was(99.20±1.75)%.The preparation had anti-inflammatory,analgesic and expectorant actions and to obvious acute and long-term toxicity was found.CONCLUSION:HHP is simple in preparation technic,controllable in quality,reliable in therapeutic effect and safe in use. |
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| Keywords: | Houyanqingshui honeyed pill glycyrrhizic acid pharmacodynamics toxicology |
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