乙型肝炎、肝硬化患者生存质量与心理状况的相关性研究

目的了解乙肝、肝硬化患者的生存质量和心理状况,探讨两者之间的关系。方法对50例病例和100例对照进行生存质量测定量表(SF-36)、焦虑自评量表(SAS)和抑郁自评量表(SDS)测定,以评价病例和对照的生存质量和心理状况。将乙肝、肝硬化患者的生存质量与心理状况进行相关性分析,并用多因素逐步回归的方法研究心理状况与乙肝、肝硬化患者生存质量各纬度的关系。结果与正常对照组相比,乙肝、肝硬化患者的生存质量总评分以及各纬度(躯体健康、躯体角色功能、躯体疼痛、总体健康、活力、社会功能、情绪角色功能、心理健康)分值均降低;病例组的SAS总分和SDS总分均高于正常健康人群(P<0.05);乙肝、肝硬化患者焦虑、抑郁得分与其生存质量的各个纬度相关分析结果显示:乙肝、肝硬化患者焦虑程度与躯体角色功能、活力、情绪角色功能得分呈负相关;抑郁程度与躯体角色功能、总体健康、活力、情绪角色功能得分呈负相关,抑郁主要与社会功能和心理健康存在多元线形关系,焦虑主要与情绪角色功能有关。结论乙型肝炎、肝硬化患者的生存质量较正常人群低,患者的抑郁、焦虑情绪可能影响其生存质量。

Correlation Study Between Quality of Life in Patients with Hepatic Cirrhosis After Hepatitis B and Mental Status

Objective To assess the health-related quality of life(QOL)and mental status among patients with cirrhosis developed from chronic hepatitis B and explore the relationship between the two variables.Methods 50 patients with cirrhosis developed from chronic hepatitis B were tested by using the SF-36 questionnaires to assess QOL.SAS and SDS were used to test their mental status.100 healthy controls were tested by the same questionnaires.The correlation between QOL of patients with cirrhosis developed from chronic hepatitis B and mental status was analysed.Results The score of general quality of life and seven domains(physical functioning,role limitations due to physical functioning,general health perception,role limitations.due to emotional functioning,social functioning,and vitality)of patients with cirrhosis developed from chronic hepatitis B were lower than that of controls.The total scores of SAS and SDS of patients with cirrhosis developed from chronic hepatitis B were higher than that of controls.There was negative correlation between life quality and anxiety and depression.social functioning,physical health and depression had the multiple linear regression relation.Emotional functioning and anxiety had multiple linear regression relation.Conclusion Quality of life of patients with cirrhosis developed from chronic hepatitis B were lower than quality of life of controls.Mental status was closely corelated with quality of life for patients with cirrhosis developed from chronic hepatitis B.