Voltage-gated sodium channel activity promotes prostate cancer metastasis in vivo |
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Authors: | Yildirim Senay Altun Seyhan Gumushan Hatice Patel Anup Djamgoz Mustafa B A |
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Institution: | Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Turkey. |
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Abstract: | Epigenetic upregulation of voltage-gated sodium channels (VGSCs) has been reported in a number of carcinoma cell lines and tissues. Furthermore, a large body of experimental evidence suggested that functional VGSC expression enhances various in vitro cell behaviours, such as directional motility, that would be involved in the metastatic cascade. However, it is not known if VGSC activity promotes metastasis in vivo. Here, using the Copenhagen rat model of prostate cancer and blocking VGSC activity in primary tumours with tetrodotoxin, we show (1) that the number of lung metastasis is reduced by >40% and (2) that lifespan is significantly improved. |
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Keywords: | Prostate cancer Metastasis Dunning cell Mat-LyLu Voltage-gated sodium channel Tetrodotoxin |
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